Protein Alignment Shc and shc-1

DIOPT Version :9

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_490799.2
• Gene: shc-1 / 3565745
• WormBaseID: WBGene00018788
• Length: 316
• Species: Caenorhabditis elegans
• Alignment Length: 387
• Identity: 104/387 - (26%)
• Similarity: 155/387 - (40%)
• Gaps: 108/387 - (27%)

  Fly    31 GVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAGLKSA-----------GKRRLTNF 84
            ||:.:..|.|.|.|..|:..:..|.|.|:..|||..|....|:.:|           |:.:..||
 Worm    16 GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENF 80

  Fly    85 ISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGD--NDTLDFLAYIAKNE 147
            ..|            ||:||:.:.:  ::...:|..|.....||.:.|.  .||.....|||||:
 Worm    81 PVD------------INISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNK 131

  Fly   148 DEW-RACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPSADCNINQSCKENVKEYYNDLPNK 211
            |.. |.|:|:         .|..:.|...:...|:: :|...|..|.:.|         ||
 Worm   132 DGTDRRCHVV---------FIEDVHKLIDVLTTAIN-VNTFDAQANASTS---------ND---- 173

  Fly   212 LPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNSPPPDQTTNKLGHFDPLQATT 276
             ...||.|..:. :..||              |....||                     .:|.|
 Worm   174 -GFTVPAPPMRH-RSSLH--------------RQSFVSN---------------------CRAPT 201

  Fly   277 AANSVLPSVRDVFDGPQCPLTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGK 341
            ....|:               .:||:|..:||..::.||:.:||||||:|....|:|||:|...:
 Worm   202 VTEDVV---------------GKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAE 251

  Fly   342 TP-KHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISE----DSELVLRNPVRRPQQD 398
            .. |||:|:|....|||:||.|.:||.||:||..:.:.:.||    ::.|.|..||..|..|
 Worm   252 NEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	42/160 (26%)
		SH2_SHC	293..396	CDD:198179	42/107 (39%)
shc-1	NP_490799.2	PTB	14..150	CDD:214675	42/156 (27%)
		SH2_SHC	203..311	CDD:198179	43/122 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167076
Domainoid	1	1.000	73	1.000	Domainoid score	I6032
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I3224
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S5640
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		oto18579
orthoMCL	1	0.900	-	-		OOG6_108540
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8103
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780