DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shc and shc-1

DIOPT Version :10

Sequence 1:NP_524683.2 Gene:Shc / 44052 FlyBaseID:FBgn0015296 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_490799.2 Gene:shc-1 / 3565745 WormBaseID:WBGene00018788 Length:316 Species:Caenorhabditis elegans


Alignment Length:387 Identity:104/387 - (26%)
Similarity:155/387 - (40%) Gaps:108/387 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 GVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAGLKSA-----------GKRRLTNF 84
            ||:.:..|.|.|.|..|:..:..|.|.|:..|||..|....|:.:|           |:.:..||
 Worm    16 GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENF 80

  Fly    85 ISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGD--NDTLDFLAYIAKNE 147
            ..|            ||:||:.:.:  ::...:|..|.....||.:.|.  .||.....|||||:
 Worm    81 PVD------------INISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNK 131

  Fly   148 DEW-RACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPSADCNINQSCKENVKEYYNDLPNK 211
            |.. |.|:|:         .|..:.|...:...|:: :|...|..|.:.|         ||    
 Worm   132 DGTDRRCHVV---------FIEDVHKLIDVLTTAIN-VNTFDAQANASTS---------ND---- 173

  Fly   212 LPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNSPPPDQTTNKLGHFDPLQATT 276
             ...||.|..:. :..||              |....||                     .:|.|
 Worm   174 -GFTVPAPPMRH-RSSLH--------------RQSFVSN---------------------CRAPT 201

  Fly   277 AANSVLPSVRDVFDGPQCPLTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGK 341
            ....|:               .:||:|..:||..::.||:.:||||||:|....|:|||:|...:
 Worm   202 VTEDVV---------------GKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAE 251

  Fly   342 TP-KHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISE----DSELVLRNPVRRPQQD 398
            .. |||:|:|....|||:||.|.:||.||:||..:.:.:.||    ::.|.|..||..|..|
 Worm   252 NEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShcNP_524683.2 PTB_Shc 19..178 CDD:269920 42/160 (26%)
SH2_SHC 293..396 CDD:198179 42/107 (39%)
shc-1NP_490799.2 PTB 14..150 CDD:214675 42/156 (27%)
SH2_SHC 203..311 CDD:198179 43/122 (35%)

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