DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shc and Shc2

DIOPT Version :9

Sequence 1:	NP_524683.2	Gene:	Shc / 44052	FlyBaseID:	FBgn0015296	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001101535.1	Gene:	Shc2 / 314612	RGDID:	1307137	Length:	573	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	173/496 - (34%)
Similarity:	247/496 - (49%)	Gaps:	120/496 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGNRSGSGT----------------TSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFET 55
            :|:|...||                .:.|.::||..::|.||::.|||.||:||..||:||||.|
  Rat    88 SGSRGARGTPDVADEWVRKGGFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSLDFNT 152

  Fly    56 RTQLARECINRVCEAA-GLKSAGKRRLTN----FISDRPSMQHAGTNIIINVSSRALSLSNVETG 115
            |||:.||.|||:.||. |::.:.|::..|    .|..:.:::.||.:|.:|:|...|:||...|.
  Rat   153 RTQVTREAINRLHEAVPGVRGSWKKKAPNKALASILGKSNLRFAGMSISVNISVDGLNLSVPATR 217

  Fly   116 EVIANHNMPRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRF-- 178
            ::||||:|..||||||||.|..|::||:||:....|||::|||..|.::.:|.|:|:||.|||
  Rat   218 QIIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSVISTVGQAFELRFKQ 282

  Fly   179 ------------NALSRLNDPS-ADCNINQSCKENVKEYYNDLPNKLPP---------------- 214
                        ..|:.|.:.: .|..:...     .:|||.:|.|.||
  Rat   283 YLHSPPKAVVPPERLTGLEESAWGDGEVTAD-----HDYYNSIPGKEPPLGGLVDSRLAVTQPCA 342

  Fly   215 -----------------------------EVPEPQQQQVQ----------QPLHPHAPRVAQLNL 240
                                         .|| |....||          :.|:.:...:..|.|
  Rat   343 LTTLGGLGQGLSPAWRDVRGLPWDMGPSGAVP-PGDGYVQADARGPHDYEEHLYVNTQGLDALEL 406

  Fly   241 K-------KPRDRLSSNLIDLNSPPPDQTTNKLGHFDPLQATTAANSVLPSVRDVFDGP---QCP 295
            :       :|.|....:|.|:.   |.:...||.........|||:  || :.|.:..|   :.|
  Rat   407 EDTSETPLQPEDSPKKDLFDMR---PFEDALKLHECSVAAGITAAS--LP-LEDQWPSPPTRRAP 465

  Fly   296 -------LTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEG 353
                   |..|.|:|..:||..:|:||:.|||||||:|....|||||||:....||||||:||||
  Rat   466 IAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSITNPGQYVLTGMHAGQPKHLLLVDPEG 530

  Fly   354 VVRTKDRIFDSISHLINYHWAHALPIISEDSELVLRNPVRR 394
            ||||||.:|:||||||:||..:.|||::.:|||.||..|.|
  Rat   531 VVRTKDVLFESISHLIDYHLKNGLPIVAAESELHLRGVVSR 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	75/163 (46%)
Shc	NP_524683.2	SH2_SHC	293..396	CDD:198179	60/109 (55%)
Shc2	NP_001101535.1	PTB_Shc	116..285	CDD:269920	77/168 (46%)
Shc2	NP_001101535.1	SH2_SHC	470..573	CDD:198179	59/102 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353526
Domainoid	1	1.000	143	1.000	Domainoid score	I4524
eggNOG	1	0.900	-	-		E1_KOG3697
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2835
OMA	1	1.010	-	-		QHG49816
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm44613
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10337
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870