DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shc and Shc4

DIOPT Version :9

Sequence 1:NP_524683.2 Gene:Shc / 44052 FlyBaseID:FBgn0015296 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_950187.1 Gene:Shc4 / 271849 MGIID:2655364 Length:626 Species:Mus musculus


Alignment Length:467 Identity:173/467 - (37%)
Similarity:242/467 - (51%) Gaps:89/467 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPKNGDAGNRSGSGTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECIN 65
            :|..|:...||    ..||  .|...::|.|:.:.|||.||:||..||:||||..|||:.||.|:
Mouse   165 LPGPGEPSPRS----KQDG--PPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAIS 223

  Fly    66 RVCEAA-GLKSAGKRR------LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNM 123
            |:|||. |...|.|:|      ||..:. :.::|.:|.||.:.||:.:|:|.|::..::||||.|
Mouse   224 RLCEAVPGAHGAIKKRKAPVKFLTTVLG-KSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQM 287

  Fly   124 PRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPS 188
            ..||||||||.||.|::||:||:....|||::|||..|.::|:|.|||:||.|||.  ..|.:||
Mouse   288 QSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFK--QYLKNPS 350

  Fly   189 ADCNINQSCKENV----------KEYYNDLPNKLPPE--------VPEPQQQQVQQPLHPHAPRV 235
                :|...:|.|          .:|||.:|.|.|||        ..:...|....|:  ...::
Mouse   351 ----LNTWEREEVLVDGAPEDRDHDYYNSIPGKQPPEGGISDVRIQAQATDQMAYCPI--RCEKL 409

  Fly   236 AQLNLKKPRDRLSSNLIDLNSP---PPDQT----TNKLGHF-------DPLQATTAA-------- 278
            ..|........:..|.:..:.|   |.::.    |..|.||       ||....|.|        
Mouse   410 CYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQGDTPSLRHFWRVDLFDDPCYVNTQALQSMHSYA 474

  Fly   279 ---NSVLPSVRDVFDGPQCPLTA-------------------EVW----FHAGISRPISERLLQQ 317
               :|.||.......| :.|.|.                   ::|    ||..:||..:|:||.:
Mouse   475 GNQSSALPQGSPWHLG-KAPETVQPGATAKPGSALALPHIRQQLWDEECFHGKLSRGAAEKLLVK 538

  Fly   318 DGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISE 382
            |||||||||....||:||:||:|...|||||:||||.|||||.:||::.|||.||..:.|||||.
Mouse   539 DGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMDNNLPIISS 603

  Fly   383 DSELVLRNPVRR 394
            .||:.|:.|:|:
Mouse   604 GSEVRLKQPIRK 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShcNP_524683.2 PTB_Shc 19..178 CDD:269920 77/165 (47%)
SH2_SHC 293..396 CDD:198179 57/125 (46%)
Shc4NP_950187.1 CH2 1..185 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..76
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..182 6/22 (27%)
PTB_Shc 181..347 CDD:269920 78/168 (46%)
CH1 370..521 29/153 (19%)
SH2_SHC 513..614 CDD:198179 54/100 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849849
Domainoid 1 1.000 143 1.000 Domainoid score I4622
eggNOG 1 0.900 - - E1_KOG3697
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H19567
Inparanoid 1 1.050 276 1.000 Inparanoid score I2925
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49816
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001057
OrthoInspector 1 1.000 - - otm42548
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10337
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X710
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.860

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