Protein Alignment Shc and Shc3

DIOPT Version :10

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_033193.3
• Gene: Shc3 / 20418
• MGIID: 106179
• Length: 594
• Species: Mus musculus
• Alignment Length: 494
• Identity: 182/494 - (36%)
• Similarity: 249/494 - (50%)
• Gaps: 107/494 - (21%)

  Fly     2 PKNGDA--GNRSGSGTTS----------------DGCIYPDDVIMGVGVAFNVRYTGCVEVKTSM 48
            |..|.|  |:|:.:.:.|                .|..:..|.::|.||.:.|:|.||:||..||
Mouse   105 PDGGSATPGSRAPAASMSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSM 169

  Fly    49 KSLDFETRTQLARECINRVCEAA-GLKSAGKRR-----LTNFISDRPSMQHAGTNIIINVSSRAL 107
            :||||.||||:.||.|:|||||. |.|.|.|:|     :.:.|..:.::|.||.:|.:.:|:.:|
Mouse   170 RSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASL 234

  Fly   108 SLSNVETGEVIANHNMPRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGK 172
            :|...::.::||||:|..||||||||.||.|::||:||:....|||::|||..|.::|:|.:||:
Mouse   235 NLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQ 299

  Fly   173 AFALRFNALSRLNDPS---ADCNINQSCKENVKE---------YYNDLPNKLPPEVPEPQQ-QQV 224
            ||.|||.  ..|..||   |..:..||..|...|         |||.:|.|:||    |.. ...
Mouse   300 AFELRFK--QYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPP----PGGFLDA 358

  Fly   225 QQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNSPPPDQTTNKLGHFD------------------- 270
            :....||||..||...|:.......:|.|.......:...:.|..|
Mouse   359 RLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGETPT 423

  Fly   271 -------PLQATTAANSVLPSV--RDVFD-------------GP--------QC--PLT------ 297
                   |.|...||.|...|.  :|:||             ||        :|  |:|
Mouse   424 YVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDA 488

  Fly   298 -------AEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVV 355
                   ||.|:...:||..:|.||::|||||||:|....|.:||||:.....|||||:||||.:
Mouse   489 RMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTI 553

  Fly   356 RTKDRIFDSISHLINYHWAHALPIISEDSELVLRNPVRR 394
            |||||:|||||||||||...:|||:|..|||.|:.||.|
Mouse   554 RTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVER 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	76/164 (46%)
		SH2_SHC	293..396	CDD:198179	60/117 (51%)
Shc3	NP_033193.3	PTB_Shc	139..310	CDD:269920	78/172 (45%)
		SH2_SHC	492..594	CDD:198179	57/101 (56%)