Protein Alignment Shc and shc4

DIOPT Version :9

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: XP_017948152.2
• Gene: shc4 / 100490718
• XenbaseID: XB-GENE-490134
• Length: 585
• Species: Xenopus tropicalis
• Alignment Length: 426
• Identity: 166/426 - (38%)
• Similarity: 241/426 - (56%)
• Gaps: 72/426 - (16%)

  Fly    21 IYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAA-GLKSAGKRRL--T 82
            |.|..|.|  |.::.|||.||:||..||:||||.||||:.||.|:|:|||. |.|.|.|:|.  .
 Frog   172 ISPSSVRM--GPSYCVRYMGCIEVLQSMRSLDFGTRTQVTREAISRLCEAVPGAKGATKKRKPPV 234

  Fly    83 NFISD---RPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGDNDTLDFLAYIA 144
            .|:|.   :.::|.:|.|:.:::|:.:|.|:|.:|.:|:|||:|..||||||||.||.|::||:|
 Frog   235 KFLSSILGKSNLQFSGMNVQLSISTNSLILTNSDTQQVVANHHMQSISFASGGDPDTTDYVAYVA 299

  Fly   145 KNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFN------ALSRLNDPSADCNINQSCKEN--- 200
            |:....|||:::||....::|:|..||:||.|||.      :|...|| ||:.:||...::|
 Frog   300 KDPVNQRACHIMECTNNLAQDVINAIGQAFELRFKQFLKSPSLIDTND-SAELDINILAQKNEDK 363

  Fly   201 -VKEYYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLK-KPRDRLS--------------S 249
             ..||||::|.|                 .|.|..|....:| :|.:.:|              |
 Frog   364 DSHEYYNEIPGK-----------------GPSADEVLANRMKTEPMESISTYDKHHAIMDYPECS 411

  Fly   250 NLID---LNSPPPDQTTNKL------GHFD--------PLQATTAANSVLPSVRDVFDGPQCPLT 297
            |:.:   .:....|.:.:|:      |.||        |.|...:.:.:....::....|:.||.
 Frog   412 NIYENCLEDHKTMDHSASKVLKPQVGGMFDDPCYINTVPKQDNPSKSQISGKNKEKIQEPKLPLY 476

  Fly   298 A----EVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTK 358
            :    |.|:|..::|.::|.||..|||||:|||.....||||:||:|..||||||:||:|.||||
 Frog   477 SSLQHEEWYHGKMNRKVAESLLVNDGDFLIRESTTSACQYVLSGLQGGHPKHLLLVDPDGKVRTK 541

  Fly   359 DRIFDSISHLINYHWAHALPIISEDSELVLRNPVRR 394
            |.:|:|:.|||:||..:.|||||..|||.||.|||:
 Frog   542 DHVFESVIHLISYHMENELPIISSGSELYLRKPVRK 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	76/162 (47%)
		SH2_SHC	293..396	CDD:198179	58/106 (55%)
shc4	XP_017948152.2	PTB_Shc	179..338	CDD:269920	75/160 (47%)
		SH2_SHC	479..576	CDD:198179	54/96 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4566
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19567
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2813
OMA	1	1.010	-	-		QHG49816
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm47647
Panther	1	1.100	-	-	LDO	PTHR10337
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080