DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shc and shc3

DIOPT Version :9

Sequence 1:	NP_524683.2	Gene:	Shc / 44052	FlyBaseID:	FBgn0015296	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001093734.1	Gene:	shc3 / 100101768	XenbaseID:	XB-GENE-491820	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	493	Identity:	172/493 - (34%)
Similarity:	253/493 - (51%)	Gaps:	112/493 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKNGDAGNRSGS--GTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLAREC 63
            |.:.|:..|:|.|  ...|.|.::.::.|:|.||.:.|:|.||:||..||:||||.||||:.||.
Frog   140 MHQGGEDWNQSSSFVNKPSRGWLHSNEKILGPGVTYIVKYLGCIEVLRSMRSLDFNTRTQITREA 204

  Fly    64 INRVCEAA-GLKSAGKRR------LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANH 121
            .||||||. |.|...|:|      |::.:. :.::|.||.:|.:|:|:.:|::...:|.::||||
Frog   205 FNRVCEAVPGTKGVFKKRKPANKNLSSILG-KSNLQFAGMSITLNISTTSLNMMTPDTKQIIANH 268

  Fly   122 NMPRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRF-------- 178
            :|..||||||||.|..|::||:||:....|||::|||..|.::|:|.|||:||.|||
Frog   269 HMQSISFASGGDPDATDYVAYVAKDPVNRRACHILECCDGLAQDVISTIGQAFELRFKQYLQCPS 333

  Fly   179 ------NALSRLNDPSADCNINQSCKENVKEYYNDLPNKLPP---------------EVPEPQQQ 222
                  :.:..|:||...   .:.......:|||.:|||:||               :....|..
Frog   334 KIPVFPDRMQSLDDPLWQ---EEDGMTTEHQYYNSIPNKMPPPGGIIDERLKTHISNQGDNTQSV 395

  Fly   223 QVQQPLHP--HAPRVAQLNLKKPRDRLSSNLIDLNSPPP-----DQTTNKLGHFDPLQATT---- 276
            .::|..:.  |....:..|.::...|.:|  :|:.|.|.     :||:|.     |....|
Frog   396 PLEQSYYQGRHLVEKSCENFQQTVKRQAS--LDIYSLPEGKSSINQTSNA-----PTYVNTQHIN 453

  Fly   277 ---------AANSVL-PSV---------RDVFD------------------GPQC---------- 294
                     :|:|:| .||         :|:||                  ...|
Frog   454 KKTLGAIQKSADSILCKSVDSSRDISPRKDIFDMKPFEDALKNQPVLSKDASVDCSSPLLSRAAI 518

  Fly   295 -----PLTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGV 354
                 .|.:|.|:...:.|..:|:||::|||||||:|....|.|||||:.....|||||:||||.
Frog   519 LTINEELRSEPWYVGEMCRREAEKLLKRDGDFLVRKSINNPGSYVLTGMHNGLAKHLLLVDPEGT 583

  Fly   355 VRTKDRIFDSISHLINYHWAHALPIISEDSELVLRNPV 392
            ||||||:||||.||||:|..:.|||:|..|||.|:.|:
Frog   584 VRTKDRVFDSIGHLINHHLENNLPIVSSGSELCLKQPM 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	76/165 (46%)
Shc	NP_524683.2	SH2_SHC	293..396	CDD:198179	55/115 (48%)
shc3	NP_001093734.1	PTB_Shc	159..330	CDD:269920	78/171 (46%)
shc3	NP_001093734.1	SH2_SHC	523..625	CDD:198179	54/99 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4566
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2813
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm47647
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060