DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPR179 and CG43795

DIOPT Version :9

Sequence 1:	NP_001004334.3	Gene:	GPR179 / 440435	HGNCID:	31371	Length:	2367	Species:	Homo sapiens
Sequence 2:	NP_001097435.2	Gene:	CG43795 / 5740629	FlyBaseID:	FBgn0264339	Length:	1420	Species:	Drosophila melanogaster

Alignment Length:	960	Identity:	241/960 - (25%)
Similarity:	391/960 - (40%)	Gaps:	235/960 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    78 ERYEARGAGAMPGLPPSL-QGAAGTLAQ---------AANFLNMLLQANDIRESSVEEDVEWYQA 132
            |:....|:..:.|...:| :|.....||         |.|..|||.:.......||:|||....|
  Fly   413 EQQHLMGSNCVAGTSLNLGEGVVDRYAQDRFRVEAEVAVNRANMLTRIFKTTGRSVQEDVNLLHA 477

Human   133 LVRSVAEGDPRVYRALLTFN------------------PPPGASHL---QLALQ----------- 165
            .|.|:.|.|..::.|...|:                  |||....:   .||::
  Fly   478 SVLSMVEFDDDIFAAGNCFDWNEHPAQPGLFCPFAYRLPPPNLGAVFAKDLAMEYHYLGNTSEWF 542

Human   166 --ATRTGEETILQD--------LSGNWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGY 220
              |.:..|:.|.::        |..|..:|..   :.||.|:|                 ..||
  Fly   543 FLARKNAEKVIARNEQYLKSFHLYSNRTEERI---EDDTLAVK-----------------YEDG- 586

Human   221 VGDTQQVRLSPPFLECQEGRLRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQSVDINQCAS- 284
                   |.|.|:.:|..|.:   |::|.:..|:|.: :.:...:|...:|:||:.|||:||..
  Fly   587 -------RWSKPYYDCGGGNI---WMLTYTVPFFGYE-NGTYHFKGTSGIDIDLRRVDIDQCPQR 640

Human   285 -GPGW------YSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASP---------SGGLE 333
             .||.      ::.|..|...:|.|..:...||..|.|.|.||.|||  .|         :|.|.
  Fly   641 HTPGTKRPLNIFAGTDKCKQRTTMCEAIMGLGFRRGSYKCLCRKGFY--FPDIVSQHKFFNGSLL 703

Human   334 ESDFQTTGQFGFPEGRSGRLLQCLPCPEGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIF-L 397
            |.:::...........|....:||||.|||.||.|::||:......:|.::||. ||.::.:. .
  Fly   704 EEEYEKLMLGKNSTYNSNSEYECLPCAEGCDSCEDSSPCIAALNWPMRTSILAL-ACIVIGLLPP 767

Human   398 SMLVSYRCRRNKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGT 462
            :...::|.::.|.:.|:...||..:..|...:|....::|..|:::.|.|..|:|.:||::.||.
  Fly   768 AAWFTFRYQQVKVVRAASPALLRVIALGAFFIYCTNIVMYPNPNLYTCTARIWLREIGFSLTYGA 832

Human   463 IILKLYRVLQLFLSRTAQRSALLSSGRLLRHLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGH 527
            ::||.:|:..:|..|:| ::..::...||:.||:    :.|  |:.|. .|.|.:...|.|:.|.
  Fly   833 LMLKTWRISVIFRVRSA-KAVKITDAALLKRLGI----ICG--AIGTC-LLVRTLVSPPDVVVGR 889

Human   528 TPSGRHFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIALHNELLLSAAFH 592
            |......:||..|.|||.....|:|.|.||..||...|...|.|:|.|::.:|::||.||:...:
  Fly   890 TADDLKAFLCKTDWWDYTFTSMEVLFLAWGVRLCIMVRKAPSEFNESRFISMAIYNEFLLTCFLN 954

Human   593 TARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFW---KLGAPPREEMVDEVCEDELDLQ 654
            .:...|....:||...::||.||..|||..|||||..|.:   :.|...:|.:       .:..:
  Fly   955 VSMLFLQSPANPDLLYIIFFCHTQLTVTLLLALIFGSKVYIVLRSGKSHQENI-------GMGTK 1012

Human   655 HSG---------------SYLGSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAANNPHL 704
            .||               |.:.:|.....:|..|...:..:|:::|..||:  :.:|||.
  Fly  1013 ASGAKFNFRPQVRTFANPSSVTTSTVPVAAETKLSDQEALEEIRQLSMQLQ--RIQEMAP----- 1070

Human   705 PK-------------------------KRGSSCQGLG----RSFMRYLAEFPEALARQHSRDSGS 740
            ||                         ..|::.||..    :|.:..||...|  .:::|:.:.:
  Fly  1071 PKGVAVMTISSLLDGLKTPGGLMVVAAAAGATAQGHSAANRQSALPLLALNVE--MQKYSQQNNN 1133

Human   741 PGHGSLPGSSRRRLLSSSLQ-EPEGTP--ALHKSRS-----TYDQRREQDPPLLDSLLRRK---- 793
            ...|.  ||.|..:.:..|: .|..||  |.::.|:     :.|..|||       ||||.
  Fly  1134 SNGGR--GSGRTSIPTMVLETPPSSTPPSAAYEERAVNTELSGDDFREQ-------LLRRTADGH 1189

Human   794 -LAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQA 857
             :..:............||    |||..|   :|.  |:.     :.|||.|:.  |...|.||:
  Fly  1190 IICSRCLDASKEHYYCCPP----RSACDH---LGS--PKE-----EGSLSFANI--KLECMCSQS 1238

Human   858 YLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAK 907
              |:..:...:|:             |||:.|.      |..:.||:..|
  Fly  1239 --EDLDQDVGQRQ-------------RRPTVRT------AATNTPPTSCK 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR179	NP_001004334.3	EGF_CA	278..327	CDD:238011	20/56 (36%)
		7tm_3	392..632	CDD:278433	75/240 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..818		22/99 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..932		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1098..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1247..1431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1537..1557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1577..1672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1723..1757
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1823..1852
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1886..2108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2133..2212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2308..2367
CG43795	NP_001097435.2	7tm_3	754..995	CDD:278433	79/249 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001877
OrthoInspector	1	1.000	-	-		mtm8475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910