Protein Alignment Pak and CLA4

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_014101.1
• Gene: CLA4 / 855418
• SGDID: S000005242
• Length: 842
• Species: Saccharomyces cerevisiae
• Alignment Length: 865
• Identity: 271/865 - (31%)
• Similarity: 378/865 - (43%)
• Gaps: 266/865 - (30%)

  Fly    56 DDSDRKKKTLKSKIKGSKPSHTDS-------KPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWAR 113
            |.:.:|...:.:|.:....|..|:       ...:|.||||.|.||||||..||.|.|||..|.:
Yeast   150 DSNSKKSIYIATKTESDLHSWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEK 214

  Fly   114 LLMNSNISKQEQKKNPQAVLDVLKWF---------------------DNTTKQRPSS----KYMT 153
            ||.:|.|:.::...|..||:.||:::                     .::.|..|:|    |...
Yeast   215 LLKHSRITGEDWNNNSAAVIQVLQFYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNKLRN 279

  Fly   154 NAITTHSGSSLSR-----------------VSSSSPSSTPTDSELHGSNSG-----GNLIGVQLG 196
            |::.:.|.|.:|.                 ||..|.|..|.:::|..|.|.     .|:...|..
Yeast   280 NSVNSKSSSGVSSSMVSQRKTSQPPNTKSPVSLGSGSLPPINTKLPTSQSNIPRHLQNVPNQQYP 344

  Fly   197 SMTLGPN-ANNVAVAGQILGNHYQQ--QQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVS 258
            .|..|.: .|.....|.:..|:.|:  |||...||||...||.:..||.|
Yeast   345 KMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQQQQQQKQQHQQYPYHHQG--------------- 394

  Fly   259 SSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATP 323
                                   |.|.|                            :|:.:|..|
Yeast   395 -----------------------PSPSP----------------------------SPSPSPLNP 408

  Fly   324 LQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSC 388
            .:.|               ||..      |..:..|.||.::::|..
Yeast   409 YRPH---------------HNMI------NPYSKQPQSPLSSQSTQN------------------ 434

  Fly   389 STTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPT 453
                     .|.||         :|..::.|.|                           |..|
Yeast   435 ---------QAIPR---------YAQNSSPTAA---------------------------HFQP- 453

  Fly   454 IHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQ 518
                     .|.:        |.|||..|.:|.|::..:......:|...:.....|.:
Yeast   454 ---------QRTA--------PKPPISAPRAPYPSNQNATSNTHVQPVAPKNDQSTPQT------ 495

  Fly   519 IAVPQAAVAPAATPNTRAANAKKKK-----MSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASG 578
              :.||...|.|........||.||     ||..||:.||:.:....||::.:..:||.||||||
Yeast   496 --MRQAPKRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASG 558

  Fly   579 TVYTA-------------------IESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVV 624
            :||.|                   .|...|.:||||||.||:||:||||:||||||::::|.|:|
Yeast   559 SVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIV 623

  Fly   625 NYLDSYL-VSEELWVVMEYLPGGSLTDVV--------TETCMDEGQIAAVCREVLQALEFLHANQ 680
            |:|::|| ..::||||||::.||||||::        :.:.:.|.|||.:.||..|.|:|||...
Yeast   624 NFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKH 688

  Fly   681 VIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWS 745
            :|||||||||:||.....||:|||||||:::.::|||.||||||||||||||.:::|..|:|:||
Yeast   689 IIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWS 753

  Fly   746 LGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALD 810
            ||||.|||:|||||||||:||||||||||||.|::|..:.||...:.||..||.|:|..|||..:
Yeast   754 LGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEE 818

  Fly   811 LLKHPFLKLARPLASLTPLI 830
            ||.|.|..:|.....||.|:
Yeast   819 LLHHGFFNMACDPKDLTSLL 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	27/53 (51%)
		STKc_PAK_I	558..818	CDD:270814	152/287 (53%)
		S_TKc	566..817	CDD:214567	149/278 (54%)
CLA4	NP_014101.1	PH_Cla4_Ste20	62..174	CDD:270097	5/23 (22%)
		PBD	183..241	CDD:395634	28/57 (49%)
		STKc_PAK	546..826	CDD:270789	150/279 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910