DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and PERK12

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_173768.2	Gene:	PERK12 / 838963	AraportID:	AT1G23540	Length:	720	Species:	Arabidopsis thaliana

Alignment Length:	591	Identity:	130/591 - (21%)
Similarity:	212/591 - (35%)	Gaps:	141/591 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 SSST---SQHSSANEDDMLGP----QHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVA 315
            ||||   |:.|:...|..|.|    ..|....||||..|.|                   |:...
plant    46 SSSTPPLSEPSTPPPDSQLPPLPSILPPLTDSPPPPSDSSP-------------------PVDST 91

  Fly   316 PATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPT-----TTKTTAETEGTD 375
            |:..|.|..::...|.....|.|.|...|:......::..:..|:||:     |...:...:...
plant    92 PSPPPPTSNESPSPPEDSETPPAPPNESNDNNPPPSQDLQSPPPSSPSPNVGPTNPESPPLQSPP 156

  Fly   376 ATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPS 440
            |........:|..|....|:|.|..|.|.                |||...|.::..|.|.:.|.
plant   157 APPASDPTNSPPASPLDPTNPPPIQPSGP----------------ATSPPANPNAPPSPFPTVPP 205

  Fly   441 FHDDDGTHHALPTIHCP---TPTSSSRN------------------STVSFPVAVPLPPIVTPAS 484
            .....|. ...|::..|   |||.:..|                  :...|.:...:..:.....
plant   206 KTPSSGP-VVSPSLTSPSKGTPTPNQGNGDGGGGGGGYQGKTMVGMAVAGFAIMALIGVVFLVRR 269

  Fly   485 PTPASIES--PDLYTPEPTVAQVSAG-------------GPSSQV----------AGNQIAV--- 521
            ....:|:|  ...|.|.|..:..|.|             ||:..:          .||....
plant   270 KKKRNIDSYNHSQYLPHPNFSVKSDGFLYGQDPGKGYSSGPNGSMYNNSQQQQSSMGNSYGTAGG 334

  Fly   522 --PQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAI 584
              |...:..:.||::....:.:...|.||:.|     ::.|     :.:...:|:|..|.||..
plant   335 GYPHHQMQSSGTPDSAILGSGQTHFSYEELAE-----ITQG-----FARKNILGEGGFGCVYKG- 388

  Fly   585 ESSTGMEVAIKQMNL-SQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEE-LWVVMEYLPGGS 647
            ....|..||:||:.. |.|..:|... |:.::....|.::|: |..|.:|:: ..::.||:...:
plant   389 TLQDGKVVAVKQLKAGSGQGDREFKA-EVEIISRVHHRHLVS-LVGYCISDQHRLLIYEYVSNQT 451

  Fly   648 LTDVVTETCMDEGQIAAVCREVLQ-------------ALEFLHAN---QVIHRDIKSDNILLGLD 696
            |          |..:......||:             .|.:||.:   ::|||||||.||||..:
plant   452 L----------EHHLHGKGLPVLEWSKRVRIAIGSAKGLAYLHEDCHPKIIHRDIKSANILLDDE 506

  Fly   697 GSVKLTDFGFCAQISPEQSKRTTMV-GTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPY 760
            ...::.|||........|:..:|.| ||..::|||..:..:...:.|::|.|::.:|:|.|..|.
plant   507 YEAQVADFGLARLNDTTQTHVSTRVMGTFGYLAPEYASSGKLTDRSDVFSFGVVLLELVTGRKPV 571

  Fly   761 LNENPL 766
            ....||
plant   572 DQTQPL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	60/228 (26%)
		S_TKc	566..817	CDD:214567	59/220 (27%)
PERK12	NP_173768.2	STKc_IRAK	377..645	CDD:270968	59/214 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000