DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and MAPKKK5

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_569040.1	Gene:	MAPKKK5 / 836819	AraportID:	AT5G66850	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	714	Identity:	170/714 - (23%)
Similarity:	274/714 - (38%)	Gaps:	168/714 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQ 228
            |.::|.|||||:|:.|                    |.|.|:            |.       :.
plant     4 LPQISFSSPSSSPSSS--------------------LKPVAS------------YS-------ES 29

  Fly   229 QQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPER 293
            ..|..:|:.::.|..:     :.|....::.........::|.:||.:.          ||....
plant    30 PDPDRNQDRDRFHRRL-----FRFNRGRLTRQRKLRHLTDDDVLLGERR----------ASTSSS 79

  Fly   294 T-KSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMH----NNATTTLDKN 353
            | .|..||              :|:...|.|    |:|..:..|...|:..    .||......:
plant    80 TFDSGLTR--------------SPSAFTAVP----RSPSAVPLPLPLPLPEVAGIRNAANARGLD 126

  Fly   354 KNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAA 418
            ..:..|....:.:|::....|.........:..:...:...|.:|....|..|...|..|.|
plant   127 DRDRDPERLISDRTSSGPPLTSVNGGFARDSRKATENSSYQDFSPRNRNGYWVNIPTMSAPT--- 188

  Fly   419 TVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPA 483
                         :...|..|| .....|.|.||..:.| |.|:...|       .|..|:.|..
plant   189 -------------SPYMSPVPS-PQRKSTGHDLPFFYLP-PKSNQAWS-------APDMPLDTSG 231

  Fly   484 SPTPA-------SIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQA---AVAPAATPNTRAAN 538
            .|.||       |.::..:::|:|.       .|..|:...|.:.|.:   :|..:|.|....::
plant   232 LPPPAFYDITAFSTDNSPIHSPQPR-------SPRKQIRSPQPSRPSSPLHSVDSSAPPRDSVSS 289

  Fly   539 AKKKKMSDEEILEKLR-------------------TIVSVGDP-----------NRKYTKMEKIG 573
            ....::| .::....|                   :..||..|           |.::.|.:.||
plant   290 PLHPRLS-TDVTNGRRDCCNVHPLPLPPGATCSSSSAASVPSPQAPLKLDSFPMNSQWKKGKLIG 353

  Fly   574 QGASGTVYTAIESSTGMEVAIKQMNL-SQQPKKELII----NEILVMRENKHPNVVNYLDSYLVS 633
            :|..|:||.|..|.||...|:|::.| ...||....|    .||.::...:|||:|.|..|..|.
plant   354 RGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIVQYFGSETVE 418

  Fly   634 EELWVVMEYLPGGSLTDVVTETC--MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLD 696
            :..::.:||:..||:...:.:.|  |.|..:....|.:|..|.:||..:.:|||||..|:|:...
plant   419 DRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHILSGLAYLHNKKTVHRDIKGANLLVDAS 483

  Fly   697 GSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEV---VTRKQYGP----KVDLWSLGIMAIEMV 754
            |.|||.|||....::.:::. .::.|:|||||||:   |.:|...|    .||:||||...|||.
plant   484 GVVKLADFGMAKHLTGQRAD-LSLKGSPYWMAPELMQAVMQKDSNPDLAFAVDIWSLGCTIIEMF 547

  Fly   755 EGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLK 818
            .|:||:.......|::.:..: .|.|.|  .:|...:|||..|.:.....|.:|..||:|.|||
plant   548 TGKPPWSEFEGAAAMFKVMRD-SPPIPE--SMSPEGKDFLRLCFQRNPAERPTASMLLEHRFLK 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	94/284 (33%)
		S_TKc	566..817	CDD:214567	89/264 (34%)
MAPKKK5	NP_569040.1	PKc_like	346..607	CDD:419665	89/264 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960