DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and MAPKKK9

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_192588.1	Gene:	MAPKKK9 / 826407	AraportID:	AT4G08480	Length:	773	Species:	Arabidopsis thaliana

Alignment Length:	849	Identity:	182/849 - (21%)
Similarity:	312/849 - (36%)	Gaps:	242/849 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SKPSHTDSK-PN--ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVL 133
            ::.:.:::| ||  ||..|:..:.|   ||.:..            ||..:..::..|.:|...|
plant    75 TRSNSSENKIPNEDISVSTSSRYLV---FDKILA------------LMKKSPGRRGDKTSPARRL 124

  Fly   134 D----VLKWFDNTTKQRPSSKYMTNAITTHSGSS----------LSRVSSSSPSSTPTD------ 178
            |    |.:..|....:..||..:|.::...:.:|          :.|:......|.|.|
plant   125 DRSDAVRRNIDYDAGEDSSSLLITRSLDFPNRTSFRVDGVDDGEIDRIYQYIGVSGPEDFAISSD 189

  Fly   179 -------SELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQN 236
                   .|...|:....|..:.|.|...||:...||
plant   190 AWKARMEHERSSSDVVNKLKSLDLDSREAGPSGGVVA---------------------------- 226

  Fly   237 HNQHHMGISQSHSYNFVGHTVS---------SSTSQHSSANEDDMLGPQHPQQQPPPPPVASR-- 290
                    |.|.::.|.||.:|         :|....|.:|:.:.|.....::......|.:|
plant   227 --------SSSMNHKFQGHDLSEAGSIGVVVASNFTLSESNKIENLNSLRDKEIVDGDMVENRCG 283

  Fly   291 PERTKSIYTRP---------------IEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASP 340
            .||..:|..:.               |:.::|.::.:|.|         ......||
plant   284 IERKPTILVKSRGYLVHNDDVGVGGGIKGVRPPVLNVPRA---------DKEVVDGG-------- 331

  Fly   341 MMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSL 405
                   |...|:.....||  ...|:.......|  ..:...|:|..:..||.
plant   332 -------TVESKSGIEWKPT--ILVKSKGYLVSND--GGIKGVTSPVLNLRPTD----------- 374

  Fly   406 VETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSF 470
                       ...|.:.|..|..                |.....|::..|.|
plant   375 -----------KEVVDSGTVENRR----------------GIKGVRPSVLKPPP----------- 401

  Fly   471 PVAVPLPPIVTPASPTPASIESPDLYT---PEPTVAQVSAGGPSS----------------QVAG 516
              .:.|||:..|.|       |.|:.|   |:..:.:..:...||                :..|
plant   402 --VMKLPPVDLPGS-------SWDILTHFAPDSEIVRRPSSSSSSENGCDEEEAEDDKVEKEETG 457

  Fly   517 NQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVY 581
            :.....:.....|.:..|...::.....:...|      .||.|..|..:.|.:.:.||:.|:||
plant   458 DMFIQLEDTTDEACSFTTNEGDSSSTVSNTSPI------CVSGGSINTSWQKGQLLRQGSFGSVY 516

  Fly   582 TAIESSTGMEVAIKQMNLSQQPKK-----ELIINEILVMRENKHPNVVNYLDSYLVSEELWVVME 641
            .|| |..|...|:|:::|..|..:     :.:..||.::.:.:|.|::.|..:......|::.:|
plant   517 EAI-SEDGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILRYRGTDKDGSNLYIFLE 580

  Fly   642 YLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGF 706
            .:..|||.::.....:.:..|:...:::|..|::||....||||||...||:..:|:|||.|||.
plant   581 LVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGL 645

  Fly   707 C--AQISPEQSKRTTMVGTPYWMAPEVVTRKQ---YGPKVDLWSLGIMAIEMVEGEPPYLNENPL 766
            .  ::::..:|::.|:    :||||||:.||.   |....|:||||...:||..|:.||.:..|:
plant   646 AKVSKLNDIKSRKETL----FWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPV 706

  Fly   767 KALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPL-----ASL 826
            :||:.|.....||:  .|.||...:.|:.:||::..:.|.:|.:||.|||::  |||     .|.
plant   707 EALFRIRRGTLPEV--PDTLSLDARHFILKCLKLNPEERPTATELLNHPFVR--RPLPSSGSGST 767

  Fly   827 TPLI 830
            :|||
plant   768 SPLI 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	13/57 (23%)
		STKc_PAK_I	558..818	CDD:270814	87/269 (32%)
		S_TKc	566..817	CDD:214567	83/260 (32%)
MAPKKK9	NP_192588.1	PKc_like	500..755	CDD:304357	83/261 (32%)
MAPKKK9	NP_192588.1	S_TKc	501..755	CDD:214567	83/260 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910