DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and MEKK3

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_192587.1	Gene:	MEKK3 / 826406	AraportID:	AT4G08470	Length:	560	Species:	Arabidopsis thaliana

Alignment Length:	580	Identity:	137/580 - (23%)
Similarity:	243/580 - (41%)	Gaps:	117/580 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 IEDLQPAIIPMPVAPATTPATPLQNHRTPGG----ISAPAASPMMHNNATTTLDKNKNNATPTSP 362
            |:.::|.||..|      |...|.....||.    ::..|.|..:...::::.|.
plant    31 IKAVRPPIIQPP------PGRKLPLIDFPGSSWDFLTYFAPSKTVKRQSSSSSDN---------- 79

  Fly   363 TTTKTTAETE---------GTDATSTLLSATNPSCSTTPTTDPAPA-APRGSLVET--------- 408
            |:.|...|||         |..|......|||.:.|::..:..:|: |.|||:|.:
plant    80 TSDKEEVETEETRGMFVQLGDTAHEACPFATNEADSSSTVSIISPSYASRGSIVPSWLKRKFLGR 144

  Fly   409 ---ATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTV-S 469
               ...:..::.::|.:.:|.:..:.:..|....||...|.:... |:.|.......:|...: :
plant   145 VSLGFVYEGSSGSSVGSESTCSLMTPSLEFPDRISFRKKDFSEKG-PSRHVWEKRKLTRAKLIEN 208

  Fly   470 FPVAVPLPPIV-----------------------TPASPTPASIESPDLYTPEP---TVAQVSAG 508
            |.....:.|:.                       :..|.:..|:.:|.:..|:.   .....|..
plant   209 FCNPEDIEPVTSWLKGQLLGEESFASVYEAISDSSVGSESTCSLMTPSMEFPDRISFRKRDFSEE 273

  Fly   509 GPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIG 573
            |||.:|                        .:|:|:...:::|..|....:    ..:.|.:.:|
plant   274 GPSGRV------------------------KEKRKLMRNKLIENFRKPEDI----TSWLKGQLLG 310

  Fly   574 QGASGTVYTAIESSTGMEVAIKQMNL-----SQQPKKELIINEILVMRENKHPNVVNYLDSYLVS 633
            :|:..:||.|| |..|...|:|:::|     ..|...:.:..||.::.:.:|.|:|.|..:....
plant   311 RGSYASVYEAI-SEDGDFFAVKEVSLLDKGIQAQECIQQLEGEIALLSQLQHQNIVRYRGTAKDV 374

  Fly   634 EELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGS 698
            .:|::.:|.:..||:..:.....:....::...|::|..|.:||....:|||||..|:|:..:|:
plant   375 SKLYIFLELVTQGSVQKLYERYQLSYTVVSLYTRQILAGLNYLHDKGFVHRDIKCANMLVDANGT 439

  Fly   699 VKLTDFGFCAQISPEQSKRTTMV---GTPYWMAPEVVTRKQ---YGPKVDLWSLGIMAIEMVEGE 757
            |||.|||..     |.||...::   ||.:||||||:.||.   .|...|:||||...:||..|:
plant   440 VKLADFGLA-----EASKFNDIMSCKGTLFWMAPEVINRKDSDGNGSPADIWSLGCTVLEMCTGQ 499

  Fly   758 PPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 817
            .||.:..|::|.:.|.....|::  .|.||...:.|:..||:|..:.|.:|.:||.|||:
plant   500 IPYSDLKPIQAAFKIGRGTLPDV--PDTLSLDARHFILTCLKVNPEERPTAAELLHHPFV 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	84/271 (31%)
		S_TKc	566..817	CDD:214567	83/261 (32%)
MEKK3	NP_192587.1	PKc_like	302..557	CDD:328722	83/262 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910