Protein Alignment Pak and MAP3K19

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_011510193.1
• Gene: MAP3K19 / 80122
• HGNCID: 26249
• Length: 1345
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 209/918 - (22%)
• Similarity: 329/918 - (35%)
• Gaps: 262/918 - (28%)

  Fly    50 PLPKEPD----DSDRKKKTLKSKIKGSKPSHTDSKPNISYPTNF--------EHTVHVG------ 96
            |:.:|.|    :|.|.|  |.||.|.||.:          |.||        :.|:|..
Human   538 PVHQENDKHKMNSHRSK--LDSKTKTSKKT----------PQNFVISTEGPIKPTMHKTSIKTQI 590

  Fly    97 FDAVTGEFTGM--PEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTH 159
            |.|:     |:  |..|.        ..:.|||.||    :.|.......|:| .|.....|..:
Human   591 FPAL-----GLVDPRPWQ--------LPRFQKKMPQ----IAKKQSTHRTQKP-KKQSFPCICKN 637

  Fly   160 SGSSLSRVSSSSPSST-PTDSELHGSNSGGNLIGVQLGSMTLGPNANNV---------------- 207
            .|:..|.|    |.|. ||:..|:..:...:.:..::.|...||....:
Human   638 PGTQKSCV----PLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDE 698

  Fly   208 ---------AVAGQILGN-----HYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVS 258
                     |.:|:.:.|     |.:::.....:..|...|....:...||.|.|..     .:|
Human   699 NTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKV-----LIS 758

  Fly   259 ---SSTSQH--------------------SSANE----DDMLGPQHPQQQPPP-------PPVA- 288
               ||.:.|                    ||.||    .|.:.|.:..|.|..       |||:
Human   759 KEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSD 823

  Fly   289 -------SRPERT-------KSIYTRPIEDLQPAIIPMPVAPATTPATPLQ--NHRTPGGISAPA 337
                   |..|.|       ..|.|..:.|||                .|:  :|:.|
Human   824 LSIVEEVSMEESTGDRDISNNQILTTSLRDLQ----------------ELEELHHQIP------- 865

  Fly   338 ASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPR 402
                       .:....:.|.|:...:.|...:.:...|:   ||..|.|...|...:
Human   866 -----------FIPSEDSWAVPSEKNSNKYVQQEKQNTAS---LSKVNASRILTNDLE------- 909

  Fly   403 GSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNST 467
               .::.:.|:.|  .|..:.......:|:.::..:..:.|.|...:...|......|.|..||.
Human   910 ---FDSVSDHSKT--LTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSI 969

  Fly   468 VSFPVAVPLPPIVTPASPTPASIESPDLYTPE-------PTVAQVSAGGPSSQVAGNQIAVPQAA 525
                           :.....|:.:.:| |.|       ..:|.......|.|...|:.......
Human   970 ---------------SQEIMDSVNNEEL-TDELLGCLAAELLALDEKDNNSCQKMANETDPENLN 1018

  Fly   526 VA---PAATPNTRAANAKK------------------------KKMSDEEILEKLRTIVSVGDPN 563
            :.   ..:||........|                        ||:..|..|:....|:
Human  1019 LVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPIL------ 1077

  Fly   564 RKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPK----KEL--IINEILVMRENKHPN 622
              :||.|.:|:||.||||..: :|.|..:|:||:.|....|    ||.  :..|:.:::..||.|
Human  1078 --WTKGEILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVN 1139

  Fly   623 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTE-TCMDEGQIAAVCREVLQALEFLHANQVIHRDI 686
            :|.||.:.|....:.:.||::||||::.::.. ..:.|.......:::||.:.:||.|.|:||||
Human  1140 IVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDI 1204

  Fly   687 KSDNILLGLDGSVKLTDFGFCAQIS------PEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWS 745
            |.:|::|...|.:||.|||...:::      .......:|.||||||||||:....||.|.|:||
Human  1205 KGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWS 1269

  Fly   746 LGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALD 810
            :|....||..|:||..:.:.:.|::.|..:........|..|....||:..||..:...|.|||.
Human  1270 IGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQ 1334

  Fly   811 LLKHPFLK 818
            ||||.||:
Human  1335 LLKHSFLE 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	15/69 (22%)
		STKc_PAK_I	558..818	CDD:270814	93/272 (34%)
		S_TKc	566..817	CDD:214567	92/263 (35%)
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	93/273 (34%)
		S_TKc	1078..1341	CDD:214567	92/263 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910