Protein Alignment Pak and pak2

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_002935145.1
• Gene: pak2 / 733718
• XenbaseID: XB-GENE-966302
• Length: 518
• Species: Xenopus tropicalis
• Alignment Length: 847
• Identity: 348/847 - (41%)
• Similarity: 417/847 - (49%)
• Gaps: 348/847 - (41%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPP-----DMRPLPKEPDDSDRKKKT 64
            ||||||||.|::|.                       |...|     ..:|||..|:....|..:
 Frog     8 EDKPPAPPARISST-----------------------GTKDPLTSNHSHKPLPLIPEKPRNKIIS 49

  Fly    65 LKSKI-KGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKN 128
            :.|.. |||:....: :|.||.|::||||:||||||||||||||||.|||||..|||:|.|||||
 Frog    50 MFSGTEKGSRKKERE-RPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKN 113

  Fly   129 PQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSG-----SSLSRVSSSSPSSTPTDSELHGSNSGG 188
            |||||||||::|  :|.....||::.:.....|     ||......|.||:..||.:
 Frog   114 PQAVLDVLKFYD--SKHTDKQKYLSFSAPDKDGLPSGVSSAPNAKGSEPSTAATDDD-------- 168

  Fly   189 NLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFV 253
                                                                             
 Frog   169 ----------------------------------------------------------------- 168

  Fly   254 GHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPAT 318
                          ::||         :.|||.:|.|||.|||:|||.:.|      |:|..|.
 Frog   169 --------------SDDD---------KAPPPVIAPRPEHTKSMYTRSVID------PIPPPPG- 203

  Fly   319 TPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSA 383
                                                                             
 Frog   204 ----------------------------------------------------------------- 203

  Fly   384 TNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTH 448
                                                                       |.|
 Frog   204 -----------------------------------------------------------DSD--- 206

  Fly   449 HALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQ 513
                                                                          |:.
 Frog   207 --------------------------------------------------------------SAA 209

  Fly   514 VAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASG 578
            .||::                   ..||.|||||||:||||||||:|||.:|||:.|||||||||
 Frog   210 KAGDR-------------------QKKKTKMSDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASG 255

  Fly   579 TVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYL 643
            ||:|||:.:||.||||||:||.:||||||||||||||:|.|:||:||:|||:|||:||:||||||
 Frog   256 TVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVSDELYVVMEYL 320

  Fly   644 PGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCA 708
            .|||||||||||||||.||||||||.|||||||||||||||||||||:|||:|||||||||||||
 Frog   321 AGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCA 385

  Fly   709 QISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIA 773
            ||:||||||:|||||||||||||||||.||||||:|||||||||||||||||||||||:||||||
 Frog   386 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 450

  Fly   774 TNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838
            |||.||:::.:|||..|:|||::.||::|::|.||.:||:|||||||:||:||||||:|||||.|
 Frog   451 TNGTPELQKPEKLSPIFRDFLNRSLEMDVEKRGSARELLQHPFLKLAKPLSSLTPLILAAKEAMK 515

  Fly   839 GN 840
            ||
 Frog   516 GN 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	44/53 (83%)
		STKc_PAK_I	558..818	CDD:270814	208/259 (80%)
		S_TKc	566..817	CDD:214567	202/250 (81%)
pak2	XP_002935145.1	PBD	67..121	CDD:334253	43/53 (81%)
		STKc_PAK2	223..518	CDD:132986	239/295 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I787
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm49514
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110