Protein Alignment Pak and Pak4

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_081746.1
• Gene: Pak4 / 70584
• MGIID: 1917834
• Length: 593
• Species: Mus musculus
• Alignment Length: 773
• Identity: 252/773 - (32%)
• Similarity: 355/773 - (45%)
• Gaps: 201/773 - (26%)

  Fly    71 GSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDV 135
            |.|....:    ||.|:||||.||.|||....:|||:|..|..|:       :|..:.|:.::|
Mouse     3 GKKKKRVE----ISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI-------EESARRPKPLID- 55

  Fly   136 LKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTL 200
                       |:.                 ::|..|.:..|  .:.||.      |.:.|::||
Mouse    56 -----------PAC-----------------ITSIQPGAPKT--IVRGSK------GAKDGALTL 84

  Fly   201 GPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHS 265
                                           ||.:..|   |.:::|:|.
Mouse    85 -------------------------------LLDEFEN---MSVTRSNSL--------------- 100

  Fly   266 SANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTP 330
                         :::.||||..:..|...         |:....|..:||            ..
Mouse   101 -------------RRESPPPPARAHQENGM---------LEERAAPARMAP------------DK 131

  Fly   331 GGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEG--TDATSTLLSATNPSCSTTPT 393
            .|..|.|..   |:.|.:.....:.......|   |::.:..|  .:|:......:.|..||
Mouse   132 AGSRARATG---HSEAGSGSGDRRRVGPEKRP---KSSRDGPGGPQEASRDKRPLSGPDVST--- 187

  Fly   394 TDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPT 458
              |.|    |||                  |:....::...|:::|....|.....|....|...
Mouse   188 --PQP----GSL------------------TSGTKLAAGRPFNTYPRADTDHPPRGAQGEPHTMA 228

  Fly   459 PTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQ 523
            |..         |.|..|      |:|..:|...|      ||.|:   |.||..|.|...:.||
Mouse   229 PNG---------PSATGL------AAPQSSSSSRP------PTRAR---GAPSPGVLGPHASEPQ 269

  Fly   524 ------AAVAPA-----ATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGAS 577
                  |..|||     ..|..|:...:.:::|.|:....|:.:|..|||........|||:|::
Mouse   270 LAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGST 334

  Fly   578 GTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEY 642
            |.|..|...|:|..||:|:|:|.:|.::||:.||:::||:.:|.|||...:||||.:|||||||:
Mouse   335 GIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEF 399

  Fly   643 LPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFC 707
            |.||:|||:||.|.|:|.||||||..|||||..|||..|||||||||:|||..||.|||:|||||
Mouse   400 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFC 464

  Fly   708 AQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLI 772
            ||:|.|..:|.::||||||||||:::|..|||:||:||||:|.||||:|||||.||.||||:.:|
Mouse   465 AQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMI 529

  Fly   773 ATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            ..|..|.:|...|.|.:.:.|||:.|..:..:||:|.:|||||||..|.|.||:.||:
Mouse   530 RDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLM 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	21/55 (38%)
		STKc_PAK_I	558..818	CDD:270814	146/259 (56%)
Pak4	NP_081746.1	CRIB_PAK_like	10..48	CDD:238526	19/48 (40%)
		Linker	25..322		90/480 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..303		58/313 (19%)
		Protein Kinases, catalytic domain	302..593	CDD:473864	157/286 (55%)