DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and MAP4K2

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_024304397.1	Gene:	MAP4K2 / 5871	HGNCID:	6864	Length:	860	Species:	Homo sapiens

Alignment Length:	289	Identity:	116/289 - (40%)
Similarity:	171/289 - (59%)	Gaps:	6/289 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 VSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHP 621
            ||:.||..::..::::|.|..|.||.|.::.|....|:|.:.|........:..||.::||.:||
Human     7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHP 71

  Fly   622 NVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTET-CMDEGQIAAVCREVLQALEFLHANQVIHRD 685
            |||.|:.|||.::.||:.||:..||||.::...| .::|.|||.||||.|:.|..||:...||||
Human    72 NVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRD 136

  Fly   686 IKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEV--VTRK-QYGPKVDLWSLG 747
            ||..|:||.|.|.|||.|||...:::...:||.:.:||||||||||  |.|| .|....|:|:||
Human   137 IKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALG 201

  Fly   748 IMAIEMVEGEPPYLNENPLKALYLIATNG--KPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALD 810
            |.|||:.|.:||..:.:|::||.|::.:.  .|::::|.:.:..|..||...|.....:|.:|..
Human   202 ITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEK 266

  Fly   811 LLKHPFLKLARPLASLTPLIMAAKEATKG 839
            ||:|||.....|.|.||.|:..|.:...|
Human   267 LLQHPFTTQQLPRALLTQLLDKASDPHLG 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	108/265 (41%)
		S_TKc	566..817	CDD:214567	104/256 (41%)
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	103/255 (40%)
MAP4K2	XP_024304397.1	CNH	528..840	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910