DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and PAK5

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_065074.1	Gene:	PAK5 / 57144	HGNCID:	15916	Length:	719	Species:	Homo sapiens

Alignment Length:	815	Identity:	262/815 - (32%)
Similarity:	371/815 - (45%)	Gaps:	173/815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDV--------- 135
            |..||.|:||||.||.|||....:|||:|:.|..||.:: .::.:...:|..:..:
Human     8 KIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADT-ANRPKPMVDPSCITPIQLAPMKTIV 71

  Fly   136 --------------LKWFDNTTKQRPSSKYMTNAITTHSGSS--------------LSRVSSSSP 172
                          |:.|||.:..|.:|....:..|...|:|              .|:.||.|.
Human    72 RGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESD 136

  Fly   173 SSTPTDSELHGSNSGGNLIGVQLGSMTLGPNA--NNVAVAGQILGNHYQQQ-------------- 221
            ::....:|.:...|   |.|..|.....|.:|  .|..|.....|..|..:
Human   137 TTADYTTEKYREKS---LYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSAD 198

  Fly   222 -QQHLLQQQQPLLHQNHNQHHMGISQS----HSYNFVGHTV--SSSTSQHSSANEDDMLGPQHPQ 279
             ..||....:|..:.:....:...|.|    :|:.|.....  :|..|:.|.|..:...||.
Human   199 YHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPS--- 260

  Fly   280 QQPPPPPVASRPERTKSIY---TRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPM 341
                   :.....|.||.|   |.|    ||.     :...:...:.||....|.|.||....|.
Human   261 -------LDDYDRRPKSSYLNQTSP----QPT-----MRQRSRSGSGLQEPMMPFGASAFKTHPQ 309

  Fly   342 MHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLV 406
            .|:..:.|..:      .:.||......:   .|....:||         |....:...|||
Human   310 GHSYNSYTYPR------LSEPTMCIPKVD---YDRAQMVLS---------PPLSGSDTYPRG--- 353

  Fly   407 ETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRN-STVSF 470
                      .|.:..|.:.:.:||:|        |.....:|.....|.|:..|||:. ||.|:
Human   354 ----------PAKLPQSQSKSGYSSSS--------HQYPSGYHKATLYHHPSLQSSSQYISTASY 400

  Fly   471 PVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTR 535
            ..::.|               |...|.|.      |.|..|.|
Human   401 LSSLSL---------------SSSTYPPP------SWGSSSDQ---------------------- 422

  Fly   536 AANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLS 600
                :..::|.|:....|:.:||.|||........|||:|::|.|..|.|..||.:||:|:|:|.
Human   423 ----QPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLR 483

  Fly   601 QQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAV 665
            :|.::||:.||:::||:..|.|||:...||||.:|||||||:|.||:|||:||.|.|:|.|||.|
Human   484 KQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATV 548

  Fly   666 CREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPE 730
            |..||:||.:||...|||||||||:|||..||.:||:|||||||:|.|..||.::||||||||||
Human   549 CLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613

  Fly   731 VVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLD 795
            |::|..||.:||:||||||.|||::|||||.||.||:|:..|..:..|.:|:..|:||..:.|||
Human   614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLD 678

  Fly   796 QCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            ..|..|..:||:|.:||.|||||||.|.:.:.||:
Human   679 LMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	20/76 (26%)
		STKc_PAK_I	558..818	CDD:270814	144/259 (56%)
		S_TKc	566..817	CDD:214567	139/250 (56%)
PAK5	NP_065074.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		13/20 (65%)
		CRIB_PAK_like	9..55	CDD:238526	19/46 (41%)
		Linker	25..448		104/531 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..123		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..299		12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..373		12/62 (19%)
		STKc_PAK5	426..717	CDD:132989	155/288 (54%)
		S_TKc	454..700	CDD:214567	139/245 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920