DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak and PAK3

DIOPT Version :9

Sequence 1:NP_001138013.2 Gene:Pak / 44039 FlyBaseID:FBgn0267698 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_001121640.1 Gene:PAK3 / 5063 HGNCID:8592 Length:580 Species:Homo sapiens


Alignment Length:883 Identity:366/883 - (41%)
Similarity:428/883 - (48%) Gaps:359/883 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRK-------- 61
            |:||||||:|:.||   |..|..                :....:|||..|::.::|        
Human     8 EEKPPAPPLRMNSN---NRDSSA----------------LNHSSKPLPMAPEEKNKKARLRSIFP 53

  Fly    62 ---KKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFT------------------ 105
               .||.|.|.|        .:|.||.|::||||:||||||||||||                  
Human    54 GGGDKTNKKKEK--------ERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSE 110

  Fly   106 ------------------GMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
                              |:||.|||||..|||:|.||||||||||||||::|:..... :.|||
Human   111 GKMPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVN-NQKYM 174

  Fly   153 TNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNH 217
            :   .|....|.....::.||||.|.||                                     
Human   175 S---FTSGDKSAHGYIAAHPSSTKTASE------------------------------------- 199

  Fly   218 YQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQP 282
                        .||                     ...||....:.....||         :..
Human   200 ------------PPL---------------------APPVSEEEDEEEEEEED---------ENE 222

  Fly   283 PPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNAT 347
            |||.:|.|||.|||||||.:           |....:||.|                        
Human   223 PPPVIAPRPEHTKSIYTRSV-----------VESIASPAVP------------------------ 252

  Fly   348 TTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAH 412
                 ||.                                                         
Human   253 -----NKE--------------------------------------------------------- 255

  Fly   413 ATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLP 477
                                                                             
Human   256 ----------------------------------------------------------------- 255

  Fly   478 PIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKK 542
              |||  |:..:..|..||.                                   || ....||.
Human   256 --VTP--PSAENANSSTLYR-----------------------------------NT-DRQRKKS 280

  Fly   543 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL 607
            ||:|||||||||:|||||||.:|||:.||||||||||||||::.:||.|||||||||.|||||||
Human   281 KMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL 345

  Fly   608 IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQA 672
            ||||||||||||:||:|||||||||.:|||||||||.||||||||||||||||||||||||.|||
Human   346 IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 410

  Fly   673 LEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQY 737
            |:|||:||||||||||||||||:|||||||||||||||:||||||:|||||||||||||||||.|
Human   411 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 475

  Fly   738 GPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEV 802
            |||||:|||||||||||||||||||||||:|||||||||.||::..::||:.|:|||::|||::|
Human   476 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 540

  Fly   803 DRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            |||.||.:||:|||||||:||:||||||:|||||.|.:
Human   541 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNS 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PakNP_001138013.2 PBD 83..137 CDD:279166 43/89 (48%)
STKc_PAK_I 558..818 CDD:270814 217/259 (84%)
S_TKc 566..817 CDD:214567 210/250 (84%)
PAK3NP_001121640.1 PBD 69..162 CDD:307091 45/92 (49%)
STKc_PAK3 284..580 CDD:132987 246/295 (83%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149924
Domainoid 1 1.000 443 1.000 Domainoid score I538
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 668 1.000 Inparanoid score I749
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52925
OrthoDB 1 1.010 - - D425477at33208
OrthoFinder 1 1.000 - - FOG0000763
OrthoInspector 1 1.000 - - otm42283
orthoMCL 1 0.900 - - OOG6_100484
Panther 1 1.100 - - LDO PTHR48015
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1405
SonicParanoid 1 1.000 - - X799
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.940

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