DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and PAK2

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_002568.2	Gene:	PAK2 / 5062	HGNCID:	8591	Length:	524	Species:	Homo sapiens

Alignment Length:	843	Identity:	351/843 - (41%)
Similarity:	419/843 - (49%)	Gaps:	334/843 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EDKPPAPPVRLTS---NRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTL- 65
            ||||||||||::|   :.||.:.....                 ..::|||..|::...:.|.:
Human     8 EDKPPAPPVRMSSTIFSTGGKDPLSAN-----------------HSLKPLPSVPEEKKPRHKIIS 55

  Fly    66 --KSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKN 128
              ....||||....: :|.||.|::||||:||||||||||||||||.|||||..|||:|.|||||
Human    56 IFSGTEKGSKKKEKE-RPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKN 119

  Fly   129 PQAVLDVLKWFD-NTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIG 192
            |||||||||::| ||.||    ||:                    |.||.:.:  |..||
Human   120 PQAVLDVLKFYDSNTVKQ----KYL--------------------SFTPPEKD--GFPSG----- 153

  Fly   193 VQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTV 257
                  |...||........:
Human   154 ------TPALNAKGTEAPAVV-------------------------------------------- 168

  Fly   258 SSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPAT 322
                    :..|||       .::..||.:|.||:.|||||||.:.|..||
Human   169 --------TEEEDD-------DEETAPPVIAPRPDHTKSIYTRSVIDPVPA-------------- 204

  Fly   323 PLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPS 387
            |:.:....|              |..:|||.|
Human   205 PVGDSHVDG--------------AAKSLDKQK--------------------------------- 222

  Fly   388 CSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALP 452

Human   223 ----------------------------------------------------------------- 222

  Fly   453 TIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGN 517

Human   223 ----------------------------------------------------------------- 222

  Fly   518 QIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYT 582
                                  ||.||:||||:||||||||:|||.:|||:.|||||||||||:|
Human   223 ----------------------KKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFT 265

  Fly   583 AIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGS 647
            |.:.:.|.||||||:||.:||||||||||||||:|.|:||:||:||||||.:||:||||||.|||
Human   266 ATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGS 330

  Fly   648 LTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISP 712
            ||||||||||||.||||||||.|||||||||||||||||||||:|||::||||||||||||||:|
Human   331 LTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITP 395

  Fly   713 EQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGK 777
            |||||:|||||||||||||||||.||||||:|||||||||||||||||||||||:|||||||||.
Human   396 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460

  Fly   778 PEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            ||::..:|||..|:|||::|||::|::|.||.:||:|||||||:||:||||||||||||.|.|
Human   461 PELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSN 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	44/53 (83%)
		STKc_PAK_I	558..818	CDD:270814	206/259 (80%)
		S_TKc	566..817	CDD:214567	200/250 (80%)
PAK2	NP_002568.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		26/90 (29%)
		Autoregulatory region. /evidence=ECO:0000250	69..137		50/68 (74%)
		GTPase-binding. /evidence=ECO:0000250	69..112		31/43 (72%)
		PBD	73..130	CDD:307091	46/56 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..164		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..188		7/25 (28%)
		STKc_PAK2	229..524	CDD:132986	237/295 (80%)
		Nuclear localization signal	245..251		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149923
Domainoid	1	1.000	443	1.000	Domainoid score	I538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I749
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm42283
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940