DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and stk25a

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_005165982.1	Gene:	stk25a / 449653	ZFINID:	ZDB-GENE-041010-92	Length:	424	Species:	Danio rerio

Alignment Length:	283	Identity:	120/283 - (42%)
Similarity:	176/283 - (62%)	Gaps:	4/283 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 LEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIINEIL 613
            |:.:|...|..:|...:||:|:||:|:.|.||..|.:.|...||||.::|.: :.:.|.|..||.
Zfish     4 LQNIRNQNSRLNPEEYFTKLERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEIT 68

  Fly   614 VMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHA 678
            |:.:...|.|..|..|||...:||::||||.|||..|::....::|..||.:.||:|:.|::||:
Zfish    69 VLSQCDSPYVTKYYGSYLTGSKLWIIMEYLGGGSALDLLRPGTLEEVYIATILREILKGLDYLHS 133

  Fly   679 NQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDL 743
            .:.||||||:.|:||...|.|||.|||...|::..|.||.|.||||:||||||:.:..|..|.|:
Zfish   134 ERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADI 198

  Fly   744 WSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASA 808
            |||||.|||:.:||||....:|::.|:||..|..|.:  :...|.||:||::.||..|...|.:|
Zfish   199 WSLGITAIELAKGEPPNAELHPMRVLFLIPKNNPPTL--EGSYSKAFKDFVEACLNKEPRFRPTA 261

  Fly   809 LDLLKHPFL-KLARPLASLTPLI 830
            .:||||.|: :..:..:.|:.||
Zfish   262 KELLKHKFITRYTKKTSYLSELI 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	115/261 (44%)
		S_TKc	566..817	CDD:214567	112/251 (45%)
stk25a	XP_005165982.1	STKc_MST3_like	20..291	CDD:270786	116/267 (43%)
stk25a	XP_005165982.1	S_TKc	20..270	CDD:214567	112/251 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910