DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and fray

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	146/448 - (32%)
Similarity:	205/448 - (45%)	Gaps:	83/448 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 TNHHSSASSFSSFPS-FHDDDGTHHAL---------PTIHCPTPTSSSRNSTVSFPV-------A 473
            |.......|.:..|| :...|...|.:         |....|.|.::.|:.  |.|.       .
  Fly    75 TEQEQRRESENEHPSVYRQQDEEFHPIKKEEPQKTPPISKQPRPRNTPRSQ--SQPAINNRRRPG 137

  Fly   474 VPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAAN 538
            .|.|..|.|.:.|.:|          .::..:.|...|:.|||       ||..|.|     ||.
  Fly   138 TPPPHTVAPGNGTASS----------RSMTSIPANLSSNNVAG-------AATLPGA-----AAP 180

  Fly   539 AKKKKMSDEEILEKLRTIVSVGDPNRK--YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ 601
            .:|...                 ||.|  |...:.||.||:..|:.|.......:.|||::||.:
  Fly   181 PEKYTW-----------------PNSKDDYELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEK 228

  Fly   602 -QPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-----TETC---- 656
             ....:.::.||..|....|.|||.|..|::|.||||:|:..|.||||.|::     |..|
  Fly   229 WNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGV 293

  Fly   657 MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQIS-----PEQSK 716
            .||..||.|.:|||:.||:.|:|..||||||:.|||:|.||::::.|||..|.::     ..|..
  Fly   294 FDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKV 358

  Fly   717 RTTMVGTPYWMAPEVVTRKQ-YGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEI 780
            |.|.||||.||||||:.:.. |..|.|:||.||.||||..|..||....|:|.|.|...|..|.:
  Fly   359 RHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTL 423

  Fly   781 ----KEKDKLSS---AFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIM 831
                .:||:..:   .|:..:.:||:.|..:|.:|.:||||.|.|.|:....||..::
  Fly   424 DTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	112/284 (39%)
		S_TKc	566..817	CDD:214567	108/273 (40%)
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	108/275 (39%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840