DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and MAP3K4

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_005913.3	Gene:	MAP3K4 / 4216	HGNCID:	6856	Length:	1608	Species:	Homo sapiens

Alignment Length:	566	Identity:	151/566 - (26%)
Similarity:	237/566 - (41%)	Gaps:	94/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 TRPIEDLQPAIIPMPVAPATTPATP---------LQNHRTPGGISAPAASPM------MHNNATT 348
            |||....|.......:.||...|.|         |.| ...|.:.....||:      :|.|:..
Human  1087 TRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMN-ECIGHVIGKPHSPVTGLYLAIHRNSPR 1150

  Fly   349 TLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHA 413
            .:...:.::.|.:|.....|.|...|.:.                  |:.|...||    ..|.|
Human  1151 PMKVPRCHSDPPNPHLIIPTPEGFSTRSM------------------PSDARSHGS----PAAAA 1193

  Fly   414 TTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPP 478
            ..|||.||.|..:.....:....|..|.||..|:  ::|          ..:...|....:....
Human  1194 AAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGS--SVP----------ENDRLASIAAELQFRS 1246

  Fly   479 IVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQ-------VAGNQIAVPQAAVAPAATPNTRA 536
            :...:|||    |..|    ||...:..:.|.:.:       ::.::....:.....|...:.|.
Human  1247 LSRHSSPT----EERD----EPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRL 1303

  Fly   537 ANAKK-KKMSDEEIL-------EKLRTIVSVG--DPNRKYTKMEKIGQGASGTVYTAIESSTGME 591
            ...|: ::|..:.|:       :....::.||  ....|:.:..|||:|..|.|||.|...||..
Human  1304 FEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGEL 1368

  Fly   592 VAIKQMNLSQQPKKEL--IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTE 654
            :|:|::.......|.:  ..:|:.:....||||:|.|....|..||:::.|||...|:|.: |:.
Human  1369 MAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE-VSR 1432

  Fly   655 TCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFC-------AQISP 712
            ..:.|..|....:::..|:..||.:.::|||||..||.|...|.:||.||| |       ||..|
Human  1433 LGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFG-CSVKLKNNAQTMP 1496

  Fly   713 EQSKRTTMVGTPYWMAPEVVTRKQ---YGPKVDLWSLGIMAIEMVEGEPPYLN-ENPLKALYLIA 773
            .:...|  :||..:|||||:||.:   :|...|:||||.:.||||.|:.|:.. |:..:.:|.:.
Human  1497 GEVNST--LGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG 1559

  Fly   774 TNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKL 819
            ...||.|.|  :||...:|||..|||.:...|.:|..||.|.|:|:
Human  1560 MGHKPPIPE--RLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	98/274 (36%)
		S_TKc	566..817	CDD:214567	94/263 (36%)
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1190		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1231		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1274		8/37 (22%)
		STKc_MEKK4	1342..1601	CDD:270796	95/264 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910