DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and stk24b

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_005165890.1	Gene:	stk24b / 406786	ZFINID:	ZDB-GENE-040426-2841	Length:	432	Species:	Danio rerio

Alignment Length:	272	Identity:	118/272 - (43%)
Similarity:	172/272 - (63%)	Gaps:	4/272 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 DPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIINEILVMRENKHPNVV 624
            ||...:||:|:||:|:.|.|:..|::.|...||||.::|.: :.:.|.|..||.|:.:...|.|.
Zfish    19 DPEELFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPFVT 83

  Fly   625 NYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSD 689
            .|..|||...:||::||||.|||..|::....:||.|||.:.||:|:.||:||:.:.||||||:.
Zfish    84 KYYGSYLKDTKLWIIMEYLGGGSALDLLEPGSLDETQIATILREILKGLEYLHSEKKIHRDIKAA 148

  Fly   690 NILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMV 754
            |:||...|.|||.|||...|::..|.||.|.||||:||||||:.:..|..|.|:|||||.|||:.
Zfish   149 NVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 213

  Fly   755 EGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-K 818
            :||||:.:.:|:|.|:||..|..|.:  :.......::|::.||..|...|.:|.:||||..: :
Zfish   214 KGEPPHSDLHPMKVLFLIPKNNPPTL--EGNYCKPLKEFVEACLNKEPSFRPTAKELLKHKLIVR 276

  Fly   819 LARPLASLTPLI 830
            .|:..:.||.||
Zfish   277 FAKKTSYLTELI 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	113/258 (44%)
		S_TKc	566..817	CDD:214567	111/251 (44%)
stk24b	XP_005165890.1	STKc_MST3_like	22..295	CDD:270786	116/269 (43%)
stk24b	XP_005165890.1	S_TKc	24..274	CDD:214567	111/251 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910