DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and stk4

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_989249.1	Gene:	stk4 / 394860	XenbaseID:	XB-GENE-955920	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	297	Identity:	116/297 - (39%)
Similarity:	184/297 - (61%)	Gaps:	13/297 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 KKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKE 606
            ||:|:|.:.::         |...:..:||:|:|:.|:||.|....|...|||||:.:....::
Frog    15 KKLSEESLNKQ---------PEEVFDVLEKLGEGSYGSVYKASHKETSQIVAIKQIPVESDLQE- 69

  Fly   607 LIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV--TETCMDEGQIAAVCREV 669
             ||.||.:|::....:||.|..||..:.:||:|||:..|||::|::  .:..:.|.:.|.:.:..
Frog    70 -IIKEIAIMQQCDSLHVVKYYGSYFKNTDLWIVMEFCGGGSISDIIRLRKQTLKEDETATILQST 133

  Fly   670 LQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTR 734
            |:.||:||..:.||||||:.||||..:|:.||.|||...|::...:||.|::|||:||||||:..
Frog   134 LKGLEYLHFMRKIHRDIKAGNILLNSEGTAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE 198

  Fly   735 KQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLE 799
            ..|....|:|||||.||||.||:|||...:|::|:::|.:|..|..::.:..|..|.||::.||.
Frog   199 IGYNCVADIWSLGITAIEMAEGKPPYAEIHPMRAIFMIPSNPPPTFRKPELWSKDFVDFINLCLV 263

  Fly   800 VEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEA 836
            ...:.|:||.:||:|||:|.|:..:.|..||..|::|
Frog   264 KNPELRSSATELLQHPFIKTAKGESILRHLINEAQDA 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	105/261 (40%)
		S_TKc	566..817	CDD:214567	103/252 (41%)
stk4	NP_989249.1	STKc_MST1_2	26..281	CDD:132943	104/256 (41%)
stk4	NP_989249.1	Mst1_SARAH	431..478	CDD:314497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910