DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Slik

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	298	Identity:	105/298 - (35%)
Similarity:	163/298 - (54%)	Gaps:	18/298 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 AKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQP 603
            ||||::.:.   .|:.|     ||...:..:.::|.||.|.||.|.........|.|...|..:.
  Fly    18 AKKKRLYNN---IKMDT-----DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEE 74

  Fly   604 KKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVT--ETCMDEGQIAAVC 666
            .....:.||.::.|.||||:|...:::.:.::||:::||..||:|..::.  |..:.|.|||.||
  Fly    75 NLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVC 139

  Fly   667 REVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEV 731
            :.:.:.|.|||.|:|||||:|:.|:||.::|.|||.|||..|:......|..|.:|||||||||:
  Fly   140 KHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPEL 204

  Fly   732 V-----TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQ 791
            |     ....|..|||:|||||..||:.:.|||....:|::.|..|..:..|::::..:.|..|.
  Fly   205 VLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFN 269

  Fly   792 DFLDQCLEVEVDRRASALDLLKHPFLKL---ARPLASL 826
            |||.:.|..:...|.:...|::|.|:..   |:|:..|
  Fly   270 DFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	96/266 (36%)
		S_TKc	566..817	CDD:214567	93/257 (36%)
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	100/282 (35%)
		S_TKc	37..295	CDD:214567	93/257 (36%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840