DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Stk25

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_908938.1	Gene:	Stk25 / 373542	RGDID:	727809	Length:	426	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	115/272 - (42%)
Similarity:	173/272 - (63%)	Gaps:	4/272 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 DPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIINEILVMRENKHPNVV 624
            ||...:||:::||:|:.|.||..|::.|...||||.::|.: :.:.|.|..||.|:.:...|.:.
  Rat    15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79

  Fly   625 NYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSD 689
            .|..|||.|.:||::||||.|||..|::....::|..||.:.||:|:.|::||:.:.||||||:.
  Rat    80 RYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAA 144

  Fly   690 NILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMV 754
            |:||...|.|||.|||...|::..|.||.|.||||:||||||:.:..|..|.|:|||||.|||:.
  Rat   145 NVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELA 209

  Fly   755 EGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-K 818
            :||||..:.:|::.|:||..|..|.::...  |..|::|::.||..:...|.:|.:||||.|: :
  Rat   210 KGEPPNSDLHPMRVLFLIPKNNPPTLEGHH--SKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272

  Fly   819 LARPLASLTPLI 830
            ..:..:.||.||
  Rat   273 YTKKTSFLTELI 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	111/258 (43%)
		S_TKc	566..817	CDD:214567	108/251 (43%)
Stk25	NP_908938.1	STKc_STK25	15..291	CDD:270810	115/272 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910