DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Taok3

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001074777.1	Gene:	Taok3 / 330177	MGIID:	3041177	Length:	898	Species:	Mus musculus

Alignment Length:	307	Identity:	120/307 - (39%)
Similarity:	172/307 - (56%)	Gaps:	18/307 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPK 604
            :|..:.|.||.:    :....||...:..:.:||.|:.|.||.|..:.|...||:|:|:.|.:..
Mouse     2 RKGALKDPEIAD----LFFKDDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQT 62

  Fly   605 KEL---IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDV--VTETCMDEGQIAA 664
            .|.   |:.|:..:::.||||.:.|...||.....|:||||.. ||.:|:  |.:..:.|.:|||
Mouse    63 HEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAA 126

  Fly   665 VCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAP 729
            :....||.|.:||.:.:||||||:.||||...|.|||.|||..:..||..|    .|||||||||
Mouse   127 ITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANS----FVGTPYWMAP 187

  Fly   730 EVV---TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQ 791
            ||:   ...||..|||:|||||..||:.|.:||..|.|.:.|||.||.|..|.::.:: .:.:|:
Mouse   188 EVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSRE-WTDSFR 251

  Fly   792 DFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838
            .|:|.||......|.:|::||:|.|::..||...|..||...|:|.:
Mouse   252 RFVDYCLHKIPQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVR 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	109/267 (41%)
		S_TKc	566..817	CDD:214567	106/258 (41%)
Taok3	NP_001074777.1	PKc_like	2..314	CDD:389743	120/307 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..424
		PTZ00121	<415..881	CDD:173412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910