DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Stk4

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001101270.1	Gene:	Stk4 / 311622	RGDID:	1312035	Length:	487	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	125/307 - (40%)
Similarity:	185/307 - (60%)	Gaps:	12/307 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 TPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIK 595
            |...|....::.|..||:.|.|        .|...:..:||:|:|:.|:||.||...||..||||
  Rat     3 TVQLRNPPRRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIK 59

  Fly   596 QMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV--TETCMD 658
            |:.:....::  ||.||.:|::...|:||.|..||..:.:||:||||...||::|::  ....:.
  Rat    60 QVPVESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT 122

  Fly   659 EGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGT 723
            |.:||.:.:..|:.||:||..:.||||||:.||||..:|..||.|||...|::...:||.|::||
  Rat   123 EDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGT 187

  Fly   724 PYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSS 788
            |:||||||:....|....|:|||||.||||.||:|||.:.:|::|:::|.||..|..::.:..|.
  Rat   188 PFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSD 252

  Fly   789 AFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKE 835
            .|.||:.|||....::||:|..||:|||:|.|:..|.|..||..|.:
  Rat   253 NFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGAAILRDLINEAMD 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	111/261 (43%)
		S_TKc	566..817	CDD:214567	109/252 (43%)
Stk4	NP_001101270.1	STKc_MST1_2	26..281	CDD:132943	110/256 (43%)
Stk4	NP_001101270.1	Mst1_SARAH	433..480	CDD:402983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910