Protein Alignment Pak and Pak6

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001099968.1
• Gene: Pak6 / 296078
• RGDID: 1306213
• Length: 681
• Species: Rattus norvegicus
• Alignment Length: 827
• Identity: 261/827 - (31%)
• Similarity: 368/827 - (44%)
• Gaps: 200/827 - (24%)

  Fly    60 RKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQE 124
            ||||              ..:|.||.|.||:|.||..||...|:|.|:|..|
  Rat     3 RKKK--------------KKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQW------------- 40

  Fly   125 QKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGN 189
                 |.:||.|:        ||......:.||......:..|...  ||.||:..:     .|.
  Rat    41 -----QNILDTLR--------RPKPVVDPSRITRVQLQPMKTVVRG--SSVPTEGYI-----SGL 85

  Fly   190 LIGVQ----LGSMTL---GPNANNVAVAGQILG-NHYQQQQQHLLQQQQPLLHQNHNQH---HMG 243
            |..:|    :.|.||   .|.:...|.:..:|| :.:.......||..|......|..:   :.|
  Rat    86 LNDIQKLSAISSNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSERTDPHGVYLSCNGG 150

  Fly   244 ISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQ-------------QQPPP---PPVAS--- 289
            ....|.........|.....:..|.:...|||...|             |..||   ||:|:
  Rat   151 TPAGHRQTPWPEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGTSPPMATGRR 215

  Fly   290 --RPERTKSIYTRPIEDLQPAIIPMP-----VAPATTPATPLQNHR--------TPGGISAPAAS 339
              :..:..|...||...|..:.|..|     .:|.|..::  ..||        ||...||.::.
  Rat   216 GVKVTKHSSEEARPQSCLVGSAIGRPGGEGSPSPKTQESS--LKHRLFRSMFLSTPATGSASSSK 278

  Fly   340 PMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGS 404
            |:       .|.:||.|:....|.          .|::|.|::......|..||
  Rat   279 PV-------PLPQNKLNSAFRPPQ----------KDSSSNLVAKAQSLPSDQPT----------- 315

  Fly   405 LVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVS 469
                                                     ||...|.|    :.|||.:.|..:
  Rat   316 -----------------------------------------GTFSPLTT----SDTSSPQKSLRT 335

  Fly   470 FPVAVPLPPIVTPA-SPTP--ASIESPDLYTP-EPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAA 530
            .|...|||...:|| ||..  |.|.:.:||.| :||||:.:.||..:.:
  Rat   336 APATGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGI---------------- 384

  Fly   531 TPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIK 595
                         ::.|:....||.:|..|||........|||:|::|.|..|.|..:|.:||:|
  Rat   385 -------------VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVK 436

  Fly   596 QMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEG 660
            .|:|.:|.::||:.||:::||:.:|.|||....||||.|||||:||:|.||:|||::::..::|.
  Rat   437 MMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEE 501

  Fly   661 QIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPY 725
            |||.||..|||||.:|||..|||||||||:|||.|||.|||:|||||||||.:..||.::|||||
  Rat   502 QIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY 566

  Fly   726 WMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAF 790
            ||||||::|..|..:||:||||||.||||:|||||.:::|::|:..:..:..|::|...|:|...
  Rat   567 WMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSYKVSPVL 631

  Fly   791 QDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEAT 837
            :|||::.|..|...||:|.:||.||||........|.|||...::.|
  Rat   632 RDFLERMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQT 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	19/55 (35%)
		STKc_PAK_I	558..818	CDD:270814	137/259 (53%)
Pak6	NP_001099968.1	PBD	11..67	CDD:395634	23/81 (28%)
		STKc_PAK6	385..681	CDD:270821	147/294 (50%)