Protein Alignment Pak and Pak3

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_008771626.1
• Gene: Pak3 / 29433
• RGDID: 3251
• Length: 580
• Species: Rattus norvegicus
• Alignment Length: 883
• Identity: 364/883 - (41%)
• Similarity: 431/883 - (48%)
• Gaps: 359/883 - (40%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRK-------- 61
            |:||||||:|:.||   |..|..                :....:|||..|::.::|
  Rat     8 EEKPPAPPLRMNSN---NRDSSA----------------LNHSSKPLPMAPEEKNKKARLRSIFP 53

  Fly    62 ---KKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFT------------------ 105
               .||.|.|.|        .:|.||.|::||||:||||||||||||
  Rat    54 GGGDKTNKKKEK--------ERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSE 110

  Fly   106 ------------------GMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
                              |:||.|||||..|||:|.||||||||||||||::|:..... :.|||
  Rat   111 GKLPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVN-NQKYM 174

  Fly   153 TNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNH 217
                                |.|..|...||               .:..:.:|...|
  Rat   175 --------------------SFTSGDKSAHG---------------YIAAHQSNTKTA------- 197

  Fly   218 YQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQP 282
                      .:.||                     ...||....:.....|||         ..
  Rat   198 ----------SEPPL---------------------APPVSEEEDEEEEEEEDD---------NE 222

  Fly   283 PPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNAT 347
            |||.:|.|||.|||||||.:.:                           .|::|||
  Rat   223 PPPVIAPRPEHTKSIYTRSVVE---------------------------SIASPAA--------- 251

  Fly   348 TTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAH 412
                                                  |:...||
  Rat   252 --------------------------------------PNKEATP-------------------- 258

  Fly   413 ATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLP 477
                                                          |::.:.||:.
  Rat   259 ----------------------------------------------PSAENANSST--------- 268

  Fly   478 PIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKK 542
                             ||.                                   || ....||.
  Rat   269 -----------------LYR-----------------------------------NT-DRQRKKS 280

  Fly   543 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL 607
            ||:|||||||||:|||||||.:|||:.||||||||||||||::.:||.|||||||||.|||||||
  Rat   281 KMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL 345

  Fly   608 IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQA 672
            ||||||||||||:||:|||||||||.:|||||||||.||||||||||||||||||||||||.|||
  Rat   346 IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 410

  Fly   673 LEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQY 737
            |:|||:||||||||||||||||:|||||||||||||||:||||||:|||||||||||||||||.|
  Rat   411 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 475

  Fly   738 GPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEV 802
            |||||:|||||||||||||||||||||||:|||||||||.||::..::||:.|:|||::|||::|
  Rat   476 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 540

  Fly   803 DRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            |||.||.:||:|||||||:||:||||||:|||||.|.:
  Rat   541 DRRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	43/89 (48%)
		STKc_PAK_I	558..818	CDD:270814	217/259 (84%)
		S_TKc	566..817	CDD:214567	210/250 (84%)
Pak3	XP_008771626.1	PBD	69..162	CDD:395634	45/92 (49%)
		STKc_PAK3	284..580	CDD:132987	246/295 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343816
Domainoid	1	1.000	443	1.000	Domainoid score	I513
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I711
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm46435
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910