DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Pak2

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001380632.1	Gene:	Pak2 / 29432	RGDID:	61953	Length:	524	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	355/843 - (42%)
Similarity:	422/843 - (50%)	Gaps:	334/843 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EDKPPAPPVRLTS---NRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTL- 65
            ||||||||||::|   :.||.:.....                 ..::|||..|::...:.|.:
  Rat     8 EDKPPAPPVRMSSTIFSTGGKDPLSAN-----------------HSLKPLPSVPEEKKPRNKIIS 55

  Fly    66 --KSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKN 128
              .|..||||....: :|.||.|::||||:||||||||||||||||.|||||..|||:|.|||||
  Rat    56 IFSSTEKGSKKKEKE-RPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKN 119

  Fly   129 PQAVLDVLKWFD-NTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIG 192
            |||||||||::| ||.||    ||:                    |.||.:.:  |..||
  Rat   120 PQAVLDVLKFYDSNTVKQ----KYL--------------------SFTPPEKD--GFPSG----- 153

  Fly   193 VQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTV 257
                                                 .|.|                     :|.
  Rat   154 -------------------------------------TPAL---------------------NTK 160

  Fly   258 SSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPAT 322
            .|.||...:..:||       .:...||.:|.||:.|||||||.:.|  |  ||.||.
  Rat   161 GSETSAVVTEEDDD-------DEDAAPPVIAPRPDHTKSIYTRSVID--P--IPAPVG------- 207

  Fly   323 PLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPS 387
                                        |.|
  Rat   208 ----------------------------DSN---------------------------------- 210

  Fly   388 CSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALP 452

  Rat   211 ----------------------------------------------------------------- 210

  Fly   453 TIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGN 517
                                                                |.:|..||.
  Rat   211 ----------------------------------------------------VDSGAKSSD---- 219

  Fly   518 QIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYT 582
                               ...||.||:||||:||||||||:|||.:|||:.|||||||||||:|
  Rat   220 -------------------KQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFT 265

  Fly   583 AIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGS 647
            |.:.:.|.||||||:||.:||||||||||||||:|.|:||:||:||||||.:||:||||||.|||
  Rat   266 ATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGS 330

  Fly   648 LTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISP 712
            ||||||||||||.||||||||.|||||||||||||||||||||:|||::||||||||||||||:|
  Rat   331 LTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITP 395

  Fly   713 EQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGK 777
            |||||:|||||||||||||||||.||||||:|||||||||||||||||||||||:|||||||||.
  Rat   396 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460

  Fly   778 PEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            ||::..:|||..|:|||::|||::|::|.||.:||:|||||||:||:||||||:|||||.|.|
  Rat   461 PELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSN 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	44/53 (83%)
		STKc_PAK_I	558..818	CDD:270814	206/259 (80%)
		S_TKc	566..817	CDD:214567	200/250 (80%)
Pak2	NP_001380632.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		27/90 (30%)
		Autoregulatory region. /evidence=ECO:0000250	69..137		50/68 (74%)
		GTPase-binding. /evidence=ECO:0000250	69..112		31/43 (72%)
		PBD	73..130	CDD:395634	46/56 (82%)
		Linker	88..248		100/468 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..190		18/119 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..228		11/232 (5%)
		STKc_PAK2	229..524	CDD:132986	236/295 (80%)
		Nuclear localization signal. /evidence=ECO:0000250	245..251		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343817
Domainoid	1	1.000	443	1.000	Domainoid score	I513
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I711
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm46435
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910