Protein Alignment Pak and Pak4

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001099708.1
• Gene: Pak4 / 292756
• RGDID: 1307705
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 773
• Identity: 253/773 - (32%)
• Similarity: 360/773 - (46%)
• Gaps: 201/773 - (26%)

  Fly    71 GSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDV 135
            |.|....:    ||.|:||||.||.|||....:|||:|..|..|:       :|..:.|:.::|
  Rat     3 GKKKKRVE----ISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI-------EESARRPKPLID- 55

  Fly   136 LKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTL 200
                       |:.                 ::|..|.:..|  .:.||.      |.:.|::||
  Rat    56 -----------PAC-----------------ITSIQPGAPKT--IVRGSK------GAKDGALTL 84

  Fly   201 GPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHS 265
                                           ||.:..|   |.:::|:|.
  Rat    85 -------------------------------LLDEFEN---MSVTRSNSL--------------- 100

  Fly   266 SANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTP 330
                         :::.||||..:..|...      :|: :.|:..|  ||...
  Rat   101 -------------RRESPPPPARAHQENGM------LEE-RAALARM--APDKA----------- 132

  Fly   331 GGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTD 395
            ||......    |:.|.:.....:.......|.:::     ||......:      |....|.:.
  Rat   133 GGRGRATG----HSEAGSGSGDRRRVGPEKRPKSSR-----EGPGGPQEV------SRDKRPLSG 182

  Fly   396 PAPAAPR-GSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTP 459
            |..:.|: |||     |..|..||             ...|:::|....|          |.|..
  Rat   183 PDVSTPQPGSL-----ASETKLAA-------------GRPFNTYPRADTD----------HPPRG 219

  Fly   460 TSSSRNSTV-SFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQ 523
            |....::.. :.|.|:.|      |:|..:|...|      ||.|:   |.||..|.|...:.||
  Rat   220 TQGEPHTMAPNGPSAIGL------AAPQSSSSSRP------PTRAR---GAPSPGVLGPHASEPQ 269

  Fly   524 ------AAVAPA-----ATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGAS 577
                  |..|||     ..|..|:...:.:::|.|:....|:.:|..|||........|||:|::
  Rat   270 LAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGST 334

  Fly   578 GTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEY 642
            |.|..|...|:|..||:|:|:|.:|.::||:.||:::||:.:|.|||...:||||.:|||||||:
  Rat   335 GIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEF 399

  Fly   643 LPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFC 707
            |.||:|||:||.|.|:|.||||||..|||||..|||..|||||||||:|||..||.|||:|||||
  Rat   400 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFC 464

  Fly   708 AQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLI 772
            ||:|.|..:|.::||||||||||:::|..|||:||:||||:|.||||:|||||.||.||||:.:|
  Rat   465 AQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMI 529

  Fly   773 ATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            ..|..|.:|...|.|.:.:.|||:.|..:..:||:|.:|||||||..|.|.||:.||:
  Rat   530 RDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLM 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	21/55 (38%)
		STKc_PAK_I	558..818	CDD:270814	146/259 (56%)
Pak4	NP_001099708.1	CRIB_PAK_like	10..48	CDD:238526	19/48 (40%)
		Protein Kinases, catalytic domain	302..593	CDD:473864	157/286 (55%)