DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and Pak4

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001099708.1	Gene:	Pak4 / 292756	RGDID:	1307705	Length:	593	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	253/773 - (32%)
Similarity:	360/773 - (46%)	Gaps:	201/773 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDV 135
            |.|....:    ||.|:||||.||.|||....:|||:|..|..|:       :|..:.|:.::|
  Rat     3 GKKKKRVE----ISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI-------EESARRPKPLID- 55

  Fly   136 LKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTL 200
                       |:.                 ::|..|.:..|  .:.||.      |.:.|::||
  Rat    56 -----------PAC-----------------ITSIQPGAPKT--IVRGSK------GAKDGALTL 84

  Fly   201 GPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHS 265
                                           ||.:..|   |.:::|:|.
  Rat    85 -------------------------------LLDEFEN---MSVTRSNSL--------------- 100

  Fly   266 SANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTP 330
                         :::.||||..:..|...      :|: :.|:..|  ||...
  Rat   101 -------------RRESPPPPARAHQENGM------LEE-RAALARM--APDKA----------- 132

  Fly   331 GGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTD 395
            ||......    |:.|.:.....:.......|.:::     ||......:      |....|.:.
  Rat   133 GGRGRATG----HSEAGSGSGDRRRVGPEKRPKSSR-----EGPGGPQEV------SRDKRPLSG 182

  Fly   396 PAPAAPR-GSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTP 459
            |..:.|: |||     |..|..||             ...|:::|....|          |.|..
  Rat   183 PDVSTPQPGSL-----ASETKLAA-------------GRPFNTYPRADTD----------HPPRG 219

  Fly   460 TSSSRNSTV-SFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQ 523
            |....::.. :.|.|:.|      |:|..:|...|      ||.|:   |.||..|.|...:.||
  Rat   220 TQGEPHTMAPNGPSAIGL------AAPQSSSSSRP------PTRAR---GAPSPGVLGPHASEPQ 269

  Fly   524 ------AAVAPA-----ATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGAS 577
                  |..|||     ..|..|:...:.:::|.|:....|:.:|..|||........|||:|::
  Rat   270 LAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGST 334

  Fly   578 GTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEY 642
            |.|..|...|:|..||:|:|:|.:|.::||:.||:::||:.:|.|||...:||||.:|||||||:
  Rat   335 GIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEF 399

  Fly   643 LPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFC 707
            |.||:|||:||.|.|:|.||||||..|||||..|||..|||||||||:|||..||.|||:|||||
  Rat   400 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFC 464

  Fly   708 AQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLI 772
            ||:|.|..:|.::||||||||||:::|..|||:||:||||:|.||||:|||||.||.||||:.:|
  Rat   465 AQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMI 529

  Fly   773 ATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            ..|..|.:|...|.|.:.:.|||:.|..:..:||:|.:|||||||..|.|.||:.||:
  Rat   530 RDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLM 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	21/53 (40%)
		STKc_PAK_I	558..818	CDD:270814	146/259 (56%)
		S_TKc	566..817	CDD:214567	142/250 (57%)
Pak4	NP_001099708.1	CRIB_PAK_like	10..48	CDD:238526	19/48 (40%)
		PKc_like	302..593	CDD:304357	157/286 (55%)
		S_TKc	328..574	CDD:214567	142/245 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920