Protein Alignment Pak and Map3k19

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_038947212.1
• Gene: Map3k19 / 289001
• RGDID: 1566400
• Length: 1513
• Species: Rattus norvegicus
• Alignment Length: 911
• Identity: 203/911 - (22%)
• Similarity: 335/911 - (36%)
• Gaps: 217/911 - (23%)

  Fly    69 IKGSKPSHTDSKPNISYP----TNFEHT-----VHVGFDAVTGEFT------------------- 105
            |.|....|.|::.|...|    ||.|..     ||:.|   .||.|
  Rat   654 ITGLLEGHGDTEENRKLPIEEETNPEMNGAVPLVHITF---PGEGTPKGPARAKPNLQRRKHPVQ 715

  Fly   106 --GMPEAWAR-----LLMNSNISKQEQKKNPQAVLDV--------------------LKWFDNTT 143
              |.|...||     |..|::.:|...:..|..::.:                    |::.|:
  Rat   716 SSGSPNILARQEHGKLQTNTHRTKARNRPPPNLMVSIQASIKPNVRKNSIKTQVFPALEFMDH-- 778

  Fly   144 KQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTP-------------------TDSELHGSNSGGN 189
            :..|.||:...|..|.. .|:.:.......:.|                   ||..||..:...:
  Rat   779 RPHPPSKFQRRAPVTEK-KSMCQTQKPKKQAFPHICKNAGIKKPGVVLSVETTDPRLHFLDLKYS 842

  Fly   190 LIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVG 254
            .:..::.|.:.||..  ..:.|..:.:|.::.::|            .::|:..|..:.|...||
  Rat   843 DMFKEINSASNGPGI--YEMFGTPVYSHIREAERH------------EHRHYHEICAAPSGRSVG 893

  Fly   255 HTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRP---------IEDLQPAII 310
            :....|.|.. .||....|..:.|..:||.|.:..: ::.:.:.::.         :||
  Rat   894 NKCQPSQSDR-CANSRARLLQKRPHVKPPKPSLGLK-QKHRGLISKDKGCKGMGGHVED------ 950

  Fly   311 PMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTT------TKTTA 369
              .|:.......|..|    ..:|:...:.:.|..........:....|.|..:      |:..|
  Rat   951 --SVSEPGWQTRPSAN----DSLSSKDEAQLTHLTLIPETSPEQRETPPLSDLSIVEEIFTEECA 1009

  Fly   370 ETEG-------TDATSTL--LSATNPSCSTTPTTDP-APAAPRGSLVETATAHATTAAATVATST 424
            :.||       |.:...|  |...:|.....|:.|. |..:.:.|     ..|.:.....|....
  Rat  1010 DEEGILHNDSLTQSLGDLKALEGLHPQTPLVPSEDSWAVLSEKHS-----GKHVSPGKHDVGPLD 1069

  Fly   425 TTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPAS 489
            ..|.....:.:..|.|..|...|.           .|.||.|....|.:.|.|    ...|...|
  Rat  1070 KINADQMFTGYLEFDSLSDKSKTR-----------VSFSRYSFQEKPESAPSP----TEQPWAHS 1119

  Fly   490 IESPDLYTPEPT---VAQVSAG----GPSSQVAGNQIA--VPQAAVAPAATPN-----TRAANAK 540
            ::...|.....|   ..:||.|    |.:.::....:.  |.:.........|     |..|:.:
  Rat  1120 LDQDSLEDDSTTYQRFGKVSQGILDPGKNEELTDELLGCLVEELLAIDEKDNNSCRIMTNEADTR 1184

  Fly   541 KKKM-----------SDEEILE-KLRTIV------------------SVGDPNRK------YTKM 569
            ...:           .|.|..: ||:..:                  ::.|.:.|      :||.
  Rat  1185 DLNLVFGRRGNTIEGLDRETTDVKLQRCINGFQIYDEENFLTSYEERTLSDNSLKHEEAIFWTKG 1249

  Fly   570 EKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPK----KEL--IINEILVMRENKHPNVVNYLD 628
            |.:|:||.||||..: :|.|..:|:||:.|....|    ||.  :..|:.:::..||.|:|.||.
  Rat  1250 EILGRGAYGTVYCGL-TSLGQLIAVKQVALDSTDKLATEKEYRKLQEEVDLLKALKHVNIVAYLG 1313

  Fly   629 SYLVSEELWVVMEYLPGGSLTDVVTE-TCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNIL 692
            :.|....|.:.||::||||::.::.. ..:.|.......|::||.:.:||.|.|:|||||.:|::
  Rat  1314 TCLEENTLSIFMEFVPGGSISSIINRFGPLPETVFCKYTRQILQGVAYLHENCVVHRDIKGNNVM 1378

  Fly   693 LGLDGSVKLTDFGFCAQIS------PEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAI 751
            |...|.:||.|||...:::      .......:|.||||||||||:....||.|.|:||:|....
  Rat  1379 LMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVF 1443

  Fly   752 EMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPF 816
            ||..|:||..:.:.:.|::.|..:........|:.|....||:..||..:...|.|||.||.|.|
  Rat  1444 EMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDRFSEPAADFVRLCLTRDQHERPSALQLLTHAF 1508

  Fly   817 L 817
            :
  Rat  1509 M 1509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	19/110 (17%)
		STKc_PAK_I	558..818	CDD:270814	96/279 (34%)
Map3k19	XP_038947212.1	ANKYR	<44..226	CDD:440430
		ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1244..1509	CDD:270801	93/265 (35%)