DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak and STK39

DIOPT Version :10

Sequence 1:NP_001138013.2 Gene:Pak / 44039 FlyBaseID:FBgn0267698 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_037365.2 Gene:STK39 / 27347 HGNCID:17717 Length:545 Species:Homo sapiens


Alignment Length:387 Identity:135/387 - (34%)
Similarity:193/387 - (49%) Gaps:60/387 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 SPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEE 548
            |.:|..::.|....|   |...:|..|::..|....|.| ||.|||..|..:|            
Human     5 SGSPVHVQLPQQAAP---VTAAAAAAPAAATAAPAPAAP-AAPAPAPAPAAQA------------ 53

  Fly   549 ILEKLRTIVSVGDP--NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIIN 610
                      ||.|  ...|...|.||.||:..|..|:.......||||::||.: |...:.::.
Human    54 ----------VGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLK 108

  Fly   611 EILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV---------TETCMDEGQIAAVC 666
            ||..|.:..|||||.|..|::|.:|||:||:.|.|||:.|::         ....::|..||.:.
Human   109 EIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 173

  Fly   667 REVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQIS-----PEQSKRTTMVGTPYW 726
            :|||:.|::||.|..||||:|:.|||||.||||::.|||..|.::     .....|.|.||||.|
Human   174 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCW 238

  Fly   727 MAPEVVTR-KQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPE----IKEKD-- 784
            |||||:.: :.|..|.|:||.||.|||:..|..||....|:|.|.|...|..|.    :::|:  
Human   239 MAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMM 303

  Fly   785 -KLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLAR-------PLASLTPLIMAAKEATK 838
             |...:|:..|..||:.:..:|.:|.:|||..|.:.|:       .|.:.||.|  |:.|.|
Human   304 KKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDI--AQRAKK 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PakNP_001138013.2 PBD 83..139 CDD:395634
STKc_PAK_I 558..818 CDD:270814 110/284 (39%)
STK39NP_037365.2 STKc_OSR1_SPAK 61..337 CDD:270787 106/275 (39%)
Interaction with RELT. /evidence=ECO:0000250|UniProtKB:Q9Z1W9 310..536 18/56 (32%)
Nuclear localization signal. /evidence=ECO:0000255 360..366 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 361..423 2/3 (67%)
Caspase cleavage related site 387..391
OSR1_C 452..509 CDD:463491
Blue background indicates that the domain is not in the aligned region.

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