Protein Alignment Pak and pak2a

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001002717.1
• Gene: pak2a / 266749
• ZFINID: ZDB-GENE-021011-2
• Length: 517
• Species: Danio rerio
• Alignment Length: 846
• Identity: 347/846 - (41%)
• Similarity: 416/846 - (49%)
• Gaps: 347/846 - (41%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGD---VPPDMRPLPKEPDDSDRKKK--- 63
            ||||||||||::|.                  ...|:.|   ..|..:|||..|::...|.:
Zfish     8 EDKPPAPPVRMSST------------------FSTGIKDSMSTNPSSKPLPSVPEEKRDKPRNKI 54

  Fly    64 -TLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKK 127
             ::.|..||.|......:|.||.|::||||:|||||:||||||||||.|||||..|||:|.||||
Zfish    55 ISIFSAEKGRKKDKDKERPEISNPSDFEHTIHVGFDSVTGEFTGMPEQWARLLQTSNITKSEQKK 119

  Fly   128 NPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIG 192
            ||||||||||::|:|...|  .||:  :.|........:.|..||...|.|
Zfish   120 NPQAVLDVLKFYDSTGNSR--QKYL--SFTDKDAPQAKKGSEQSPVKDPDD-------------- 166

  Fly   193 VQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTV 257
                                                                             
Zfish   167 ----------------------------------------------------------------- 166

  Fly   258 SSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPAT 322
                        ||        :..|||.||.||:.|.|:|||.:.|      |:|
Zfish   167 ------------DD--------EDAPPPVVAPRPQHTISVYTRSVID------PIP--------- 196

  Fly   323 PLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPS 387
                        ||||                             .|:|:|
Zfish   197 ------------APAA-----------------------------IADTDG-------------- 206

  Fly   388 CSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALP 452
                                                                             
Zfish   207 ----------------------------------------------------------------- 206

  Fly   453 TIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGN 517
                                                                             
Zfish   207 ----------------------------------------------------------------- 206

  Fly   518 QIAVPQAAVAPAATPNTRAANAKKK---KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGT 579
                            ::||:.:||   ||:||||:||||||||:|||.:|||:.||||||||||
Zfish   207 ----------------SKAADKQKKGKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGT 255

  Fly   580 VYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLP 644
            |||||:.:||.||||||:||.:||||||||||||||:|.|:||:||:|||:||.:||:||||||.
Zfish   256 VYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGDELFVVMEYLA 320

  Fly   645 GGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQ 709
            |||||||||||||||.||||||||.|||||||||||||||||||||:|||:||||||||||||||
Zfish   321 GGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQ 385

  Fly   710 ISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIAT 774
            |:||||||:|||||||||||||||||.||||||:|||||||||||||||||||||||:|||||||
Zfish   386 ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT 450

  Fly   775 NGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKG 839
            ||.||::..:|||..|:|||::|||::|::|....:||:|||||||:||:||||||:|||||.|.
Zfish   451 NGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFLKLAKPLSSLTPLILAAKEAMKS 515

  Fly   840 N 840
            |
Zfish   516 N 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	43/53 (81%)
		STKc_PAK_I	558..818	CDD:270814	207/259 (80%)
		S_TKc	566..817	CDD:214567	201/250 (80%)
pak2a	NP_001002717.1	PBD	74..129	CDD:279166	43/54 (80%)
		STKc_PAK2	222..517	CDD:132986	237/295 (80%)
		S_TKc	242..493	CDD:214567	201/250 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584072
Domainoid	1	1.000	438	1.000	Domainoid score	I540
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	627	1.000	Inparanoid score	I838
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm26309
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940