Protein Alignment Pak and tea5

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_594646.1
• Gene: tea5 / 2543100
• PomBaseID: SPAC12B10.14C
• Length: 665
• Species: Schizosaccharomyces pombe
• Alignment Length: 702
• Identity: 157/702 - (22%)
• Similarity: 288/702 - (41%)
• Gaps: 126/702 - (17%)

  Fly   141 NTT--KQRPSSKYMTNAITTHSGSSLSRVSSSS-PSSTPTDSELHGSNSGGNLIGVQLGSMTLGP 202
            |:|  :....|.:..||..:::.||..|.|... .||.|.||          :|.:|.......|
pombe     4 NSTFHEHHAKSHFHNNACQSNASSSACRASEDHLVSSFPNDS----------IIDLQPSRPAPEP 58

  Fly   203 NANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQ-----HHMGISQSHSYNFVGHTVSSSTS 262
            .........:.|..|:..           |:|.:.|.     .|:...:|:..:.|.|:...|.|
pombe    59 PKKKFGYYARRLSGHFLS-----------LIHGSGNSTRSPPFHLQNQKSNGQSEVWHSSDDSGS 112

  Fly   263 ----QHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPI-----EDLQPAIIPMPVAPAT 318
                ..|.::::||   ...:.....|.::.|..:..|..:|.|     .:..|..:|:.:..:.
pombe   113 PKRLNRSRSSKEDM---YRRRSLHGLPSLSRRNSKKSSTLSRSISLHLRSESAPISLPIHLYKSY 174

  Fly   319 TPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTL--- 380
            :     .||       :|::.|.:.|:...        ::|..|||....:....:.:||::
pombe   175 S-----YNH-------SPSSLPTVLNSQAL--------SSPPVPTTPDEVSTNRLSSSTSSMNCR 219

  Fly   381 -LSATNPSCSTTPTT----------------DPAPAAPRGSLVETATAHATTAAATVATSTTTNH 428
             |...|.:.|..|.|                ..:|:|....|:......:.....:||     :|
pombe   220 NLVPDNFNISIRPNTTNYRSSIQENSNGNRDSISPSAYDAPLLHNVDTQSIDGFVSVA-----SH 279

  Fly   429 HSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPI-VTPASPTPASIES 492
            .||||:..|.     |||  |:..||.....:|...:.:||.|  ||:.|| ::||.|:|.|
pombe   280 FSSASTAESL-----DDG--HSATTIQQGDVSSYPLSRSVSTP--VPMSPISISPAKPSPQS--- 332

  Fly   493 PDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIV 557
                   |.::|.:.|.|||       ::|.||:...:..:.......::|.    .|:.:..:.
pombe   333 -------PKLSQSAVGHPSS-------SIPAAAMHKVSYSDDLMRFVAREKY----YLQIVDCLC 379

  Fly   558 SVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPN 622
            :..||...||...||.|..:...|.|.::.....|.||:.::|....:.|::.|:..:....|.|
pombe   380 TQKDPLFFYTDFTKICQQDTVGTYVARQTLDKEVVVIKRFDISAVTHRRLLLEELQRLSGLSHKN 444

  Fly   623 VVNYLDSYLVSEELWVVMEYL-PGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDI 686
            ::.|.:|:.....:|.|.||. |...|:.::.:....|..||::|.|:...|.|||.:.:.|.::
pombe   445 LIRYNESFWYLNNIWSVFEYKDPSTKLSALIPKYFFSELNIASICYEISSGLAFLHNSGIAHHNL 509

  Fly   687 KSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQY--GPKVDLWSLGIM 749
            .::.|.|.....:|:.::.|.:.....|:.|..:...|.|:     ..|.|  |...|:.|||::
pombe   510 TTECIYLTKSSCLKIGNYAFSSPYIERQTNRGAVSHVPDWL-----IEKNYKEGFMKDVKSLGLV 569

  Fly   750 AIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVE 801
            |:|:.:|:|.:..:: ::::.|.........:.:..:|..|::||.|.|:.|
pombe   570 ALEIFQGQPNFFRKS-IQSIQLTPNANVLVNRVRGLISQEFKEFLLQTLQAE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634
		STKc_PAK_I	558..818	CDD:270814	62/247 (25%)
tea5	NP_594646.1	Protein Kinases, catalytic domain	387..638	CDD:473864	60/240 (25%)