Protein Alignment Pak and shk2

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_592864.1
• Gene: shk2 / 2541468
• PomBaseID: SPAC1F5.09C
• Length: 589
• Species: Schizosaccharomyces pombe
• Alignment Length: 765
• Identity: 211/765 - (27%)
• Similarity: 295/765 - (38%)
• Gaps: 311/765 - (40%)

  Fly    83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRP 147
            :|.|.|.:|.||||.|. .|.:.|:|:.|..||.:|:|:|||..:.|:||:..|.::   :||
pombe   129 VSSPMNPKHQVHVGIDN-EGNYVGLPKEWILLLQSSSITKQECMEEPKAVIQALDFY---SKQ-- 187

  Fly   148 SSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQ 212
                                       ..|.||
pombe   188 ---------------------------LDTTSE-------------------------------- 193

  Fly   213 ILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTV-SSSTSQHSSANEDDMLGPQ 276
                                             ...|::|...|: .|||:.:|..:.|
pombe   194 ---------------------------------TKDSFSFCKETLPRSSTTSYSIRDAD------ 219

  Fly   277 HPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPM 341
                                                                             
pombe   220 ----------------------------------------------------------------- 219

  Fly   342 MHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLV 406
            .|:..||:.....|......|.||                                        :
pombe   220 KHHKLTTSGVTKMNITERCKPKTT----------------------------------------I 244

  Fly   407 ETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFP 471
            :|...|
pombe   245 QTDKKH----------------------------------------------------------- 250

  Fly   472 VAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRA 536
                   |:.|.....:.:||  :.|.:.|...|.|.                           :
pombe   251 -------IIRPFIEDKSHVES--IMTGKVTKVPVKAD---------------------------S 279

  Fly   537 ANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAI---ESSTGM--EVAIKQ 596
            .|...::|:|.:.|..|:..|:..||...:....|:||||||:||.|.   ....|:  .||||.
pombe   280 KNTLSRRMTDRQALAMLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKS 344

  Fly   597 MNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSE-ELWVVMEYLPGGSLTDVVTETCMDEG 660
            ::|..|.:||||:|||.||||:.|||:|.||||:||.| .|||||||:..|||||::.::.:.|.
pombe   345 IDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEA 409

  Fly   661 QIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPY 725
            |||.:|.|..:.::.|||..:|||||||||:||...|::|:|||||||::|...:||.|||||||
pombe   410 QIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPY 474

  Fly   726 WMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAF 790
            |||||||.:.:||.|||:||||||.|||:|.|||||.|:|::||||||.||.|.:|:.:.:|...
pombe   475 WMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNL 539

  Fly   791 QDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            :.||:.||.::...||:|.:||.|.||..|.|...|..:|.:.|..|..|
pombe   540 KSFLNSCLTIDTIFRATAAELLTHSFLNQACPTEDLKSIIFSRKANTHIN 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	24/55 (44%)
		STKc_PAK_I	558..818	CDD:270814	143/265 (54%)
shk2	NP_592864.1	PH_Cla4_Ste20	24..120	CDD:270097
		PBD	128..185	CDD:395634	24/59 (41%)
		STKc_PAK	308..567	CDD:270789	141/258 (55%)