DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and cdc7

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_596340.1	Gene:	cdc7 / 2540660	PomBaseID:	SPBC21.06c	Length:	1062	Species:	Schizosaccharomyces pombe

Alignment Length:	253	Identity:	95/253 - (37%)
Similarity:	144/253 - (56%)	Gaps:	15/253 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 IGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL--IINEILVMRENKHPNVVNYLDSYLVSE 634
            :|:||.|.||..:....|..||:|::.||:..|.:|  |..||.:::...|||:|.|..||..::
pombe    15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGSYQTND 79

  Fly   635 ELWVVMEYLPGGSLTDVVTETCMDEGQI-----AAVCREVLQALEFLHANQVIHRDIKSDNILLG 694
            .|.:::||...|||..:    |.:.|:|     |....:|||.|.:||...|||||||..|||..
pombe    80 SLCIILEYCENGSLRSI----CKNFGKIPENLVALYTFQVLQGLLYLHNQGVIHRDIKGANILTT 140

  Fly   695 LDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPP 759
            .||::||.|||...:|:..:..  ::||:||||||||:.........|:||:|...||:::|.||
pombe   141 KDGTIKLADFGVATKINALEDH--SVVGSPYWMAPEVIELVGATTASDIWSVGCTVIELLDGNPP 203

  Fly   760 YLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 817
            |.:.:|..||:.:..:..|.:  ...:|||.:.||.||.:.:.:.|.....|||||::
pombe   204 YYDLDPTSALFRMVKDEHPPL--PSNISSAAKSFLMQCFQKDPNLRIKTRKLLKHPWV 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	95/253 (38%)
		S_TKc	566..817	CDD:214567	95/251 (38%)
cdc7	NP_596340.1	STKc_Cdc7_like	10..259	CDD:270797	95/251 (38%)
cdc7	NP_596340.1	S_TKc	10..259	CDD:214567	95/251 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910