DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak and shk1

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_596626.1	Gene:	shk1 / 2539997	PomBaseID:	SPBC1604.14c	Length:	658	Species:	Schizosaccharomyces pombe

Alignment Length:	808	Identity:	271/808 - (33%)
Similarity:	366/808 - (45%)	Gaps:	277/808 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DDSDRKKKTLKSKIK---------GSKPSHT----DSKPN----ISYPTNFEHTVHVGFDAVTGE 103
            |:.::||...::.:.         ||.|:.:    .:.|.    ||.|.:.:|..||||:..|||
pombe   103 DERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGE 167

  Fly   104 FTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAI--------TTHS 160
            |||||..|..||..|.|:|.||.::||||||.:.::..      |.||:....        |...
pombe   168 FTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQ------SKKYLEEGAKPPFPRESTEKP 226

  Fly   161 GSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHL 225
            ..|:|.:||||                                                    ||
pombe   227 LLSVSALSSSS----------------------------------------------------HL 239

  Fly   226 LQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASR 290
                ||                          :|:||..|..         :|.:..|.||.:|
pombe   240 ----QP--------------------------TSATSSSSRL---------YPSRPAPTPPASS- 264

  Fly   291 PERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKN 355
                                                          ::||::
pombe   265 ----------------------------------------------SSSPLL------------- 270

  Fly   356 NATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATV 420
                 |..|.|||                    ::..:..|:|                    .|
pombe   271 -----SSQTVKTT--------------------TSNASRQPSP--------------------LV 290

  Fly   421 ATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASP 485
            ::.:|.|...|.|                  |.:..|...|:|....:
pombe   291 SSKSTDNIIRSHS------------------PVLLTPQTLSTSETKHI----------------- 320

  Fly   486 TPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEIL 550
                  .|:..||....|:.|. .|.:      :|.||...||:| |..: ..|.:::.:|..:|
pombe   321 ------RPNNSTPYQRRAETST-KPKA------VATPQKVEAPSA-PRLQ-KRAPRQQSNDSAVL 370

  Fly   551 EKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVM 615
            .||::|.:..:|...|....||||||||.||:|.:..|.:.||||:||::||||||.|:||||||
pombe   371 AKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVM 435

  Fly   616 RENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQ 680
            :.:.|.|:||::|::....|||:||||:.|||||:|||...:.||||||:|:|.|:.|:.||.|.
pombe   436 KSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENG 500

  Fly   681 VIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWS 745
            ::|||||||||||.|.|.:|||||||||||....:||||||||||||||||||||:||.|||:||
pombe   501 IVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWS 565

  Fly   746 LGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALD 810
            |||||||||||||||||||||:|||||||.|.|:|...:.|||.|.|||.:.|.|...:|.|:.:
pombe   566 LGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGE 630

  Fly   811 LLKHPFLKLARPLASLTPLIMAAKEATK 838
            ||:|||||.|.|::||.|||.:...:.|
pombe   631 LLRHPFLKQAVPVSSLIPLIKSIHHSGK 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	30/53 (57%)
		STKc_PAK_I	558..818	CDD:270814	164/259 (63%)
		S_TKc	566..817	CDD:214567	162/250 (65%)
shk1	NP_596626.1	PBD	146..200	CDD:279166	30/53 (57%)
		STKc_PAK	385..638	CDD:270789	163/252 (65%)
		S_TKc	391..637	CDD:214567	161/245 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	344	1.000	Domainoid score	I183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1936
Inparanoid	1	1.050	385	1.000	Inparanoid score	I413
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		oto102151
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
TreeFam	0	0.000	Not matched by this tool.
	10	9.990