Protein Alignment Pak and Map3k19

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_035867.2
• Gene: Map3k19 / 22625
• MGIID: 1203481
• Length: 1515
• Species: Mus musculus
• Alignment Length: 815
• Identity: 186/815 - (22%)
• Similarity: 310/815 - (38%)
• Gaps: 178/815 - (21%)

  Fly   119 NISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELH- 182
            |:.|...|..   |...|:..|:  :..||||:...|       .|:...|:..:..|......
Mouse   761 NMHKNSIKTQ---VFPALELIDH--RPHPSSKFQRRA-------PLTEKKSTHQTQKPKKQAFPR 813

  Fly   183 -GSNSGGNLIGVQLGSMTLGP-----------------NANNVAVAGQILGN----HYQQQQQHL 225
             |.::|....|:.|.:.|..|                 :|:|.....::.|.    |.::.::|
Mouse   814 IGKHAGIKKPGIPLSAETTDPRLHFLDLKYSDMFKEINSASNGPGIYEMFGTPVYCHIREAERH- 877

  Fly   226 LQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASR 290
                       .::.:..|..:.|...|.:...||.|...|.:...:|  |..|...||.|:...
Mouse   878 -----------DHRCYREIRTAPSGRCVVNKCQSSESDRCSNSRARLL--QKRQHIKPPKPLHGL 929

  Fly   291 PERTKSIYTRP---------IEDLQPAIIPMPVAPATTPATPLQNHRTPGG--ISAPAASPMMHN 344
            .::.:...::.         .||              :.:.|....::||.  :|:...:.:||.
Mouse   930 RQKHRGFISKDKGCKDMGGHTED--------------SVSEPDGQMKSPGNDFLSSKDDAQLMHL 980

  Fly   345 NATTTLDKNKNNATPTSPTT------TKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRG 403
            .....|...:....|.|..:      |:..|:.||      :|:..:.:.|.....:|....|:.
Mouse   981 IPIPELSPEQKAPAPVSDLSIVEEIFTEECADEEG------ILNDDSLTQSLGDLKEPEGLHPQA 1039

  Fly   404 SLVETATAHATTAAATVATSTTTNHHS-----SASSFSSFPSFHDDDGTHHALPTI--------- 454
            .||.:..:.|..:........:...|:     ..::...||.:.:.|.......|:
Mouse  1040 PLVPSENSWAVLSEKRSGKRVSPEKHNVEPLDKINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQ 1104

  Fly   455 ----HCPTPT-----------SSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQ 504
                ..|:||           |...|||...........|:.|......:.|...... |..:|.
Mouse  1105 ENLERAPSPTEQHWARSLEQDSLENNSTTYQTFGKISQEILDPGKNEELTDELLGCLV-EELLAL 1168

  Fly   505 VSAGGPSSQVAGNQIAVPQAAVAPAATPNT--------------RAANA-------------KKK 542
            ......|.|:..|:.......:..:...||              |..|.             :||
Mouse  1169 DEKDNNSCQIMTNEADAKNLNLVFSRRGNTIEELGRETTDVKLQRCINGFRIYDEENFLTSNEKK 1233

  Fly   543 KMSDEEILEKLRTIVSVGDPNRK----YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQP 603
            .:||:.:             |.:    :||.|.:|:||.||||..: :|.|..:|:||:.|....
Mouse  1234 TLSDKSL-------------NHEEAIFWTKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSD 1284

  Fly   604 K----KEL--IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTE-TCMDEGQ 661
            |    ||.  :..|:.:::..||.|:|.||.:.|....|.:.||::||||::.::.. ..:.|..
Mouse  1285 KLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMV 1349

  Fly   662 IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQIS------PEQSKRTTM 720
            .....|::||.:.:||.|.|:|||||.:|::|...|.:||.|||...:::      .......:|
Mouse  1350 FCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSM 1414

  Fly   721 VGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNG--KPEIKEK 783
            .||||||||||:....||.|.|:||:|....||..|:||..:.:.:.|::.|..:.  .|.:..
Mouse  1415 RGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPA- 1478

  Fly   784 DKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLK 818
             :.|....||:..||..:...|.|||.||||.|||
Mouse  1479 -RFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	5/19 (26%)
		STKc_PAK_I	558..818	CDD:270814	96/278 (35%)
Map3k19	NP_035867.2	ANKYR	<44..226	CDD:440430
		ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1246..1511	CDD:270801	94/267 (35%)