DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and Map3k19

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_035867.2	Gene:	Map3k19 / 22625	MGIID:	1203481	Length:	1515	Species:	Mus musculus

Alignment Length:	815	Identity:	186/815 - (22%)
Similarity:	310/815 - (38%)	Gaps:	178/815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 NISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELH- 182
            |:.|...|..   |...|:..|:  :..||||:...|       .|:...|:..:..|......
Mouse   761 NMHKNSIKTQ---VFPALELIDH--RPHPSSKFQRRA-------PLTEKKSTHQTQKPKKQAFPR 813

  Fly   183 -GSNSGGNLIGVQLGSMTLGP-----------------NANNVAVAGQILGN----HYQQQQQHL 225
             |.::|....|:.|.:.|..|                 :|:|.....::.|.    |.::.::|
Mouse   814 IGKHAGIKKPGIPLSAETTDPRLHFLDLKYSDMFKEINSASNGPGIYEMFGTPVYCHIREAERH- 877

  Fly   226 LQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASR 290
                       .::.:..|..:.|...|.:...||.|...|.:...:|  |..|...||.|:...
Mouse   878 -----------DHRCYREIRTAPSGRCVVNKCQSSESDRCSNSRARLL--QKRQHIKPPKPLHGL 929

  Fly   291 PERTKSIYTRP---------IEDLQPAIIPMPVAPATTPATPLQNHRTPGG--ISAPAASPMMHN 344
            .::.:...::.         .||              :.:.|....::||.  :|:...:.:||.
Mouse   930 RQKHRGFISKDKGCKDMGGHTED--------------SVSEPDGQMKSPGNDFLSSKDDAQLMHL 980

  Fly   345 NATTTLDKNKNNATPTSPTT------TKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRG 403
            .....|...:....|.|..:      |:..|:.||      :|:..:.:.|.....:|....|:.
Mouse   981 IPIPELSPEQKAPAPVSDLSIVEEIFTEECADEEG------ILNDDSLTQSLGDLKEPEGLHPQA 1039

  Fly   404 SLVETATAHATTAAATVATSTTTNHHS-----SASSFSSFPSFHDDDGTHHALPTI--------- 454
            .||.:..:.|..:........:...|:     ..::...||.:.:.|.......|:
Mouse  1040 PLVPSENSWAVLSEKRSGKRVSPEKHNVEPLDKINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQ 1104

  Fly   455 ----HCPTPT-----------SSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQ 504
                ..|:||           |...|||...........|:.|......:.|...... |..:|.
Mouse  1105 ENLERAPSPTEQHWARSLEQDSLENNSTTYQTFGKISQEILDPGKNEELTDELLGCLV-EELLAL 1168

  Fly   505 VSAGGPSSQVAGNQIAVPQAAVAPAATPNT--------------RAANA-------------KKK 542
            ......|.|:..|:.......:..:...||              |..|.             :||
Mouse  1169 DEKDNNSCQIMTNEADAKNLNLVFSRRGNTIEELGRETTDVKLQRCINGFRIYDEENFLTSNEKK 1233

  Fly   543 KMSDEEILEKLRTIVSVGDPNRK----YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQP 603
            .:||:.:             |.:    :||.|.:|:||.||||..: :|.|..:|:||:.|....
Mouse  1234 TLSDKSL-------------NHEEAIFWTKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSD 1284

  Fly   604 K----KEL--IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTE-TCMDEGQ 661
            |    ||.  :..|:.:::..||.|:|.||.:.|....|.:.||::||||::.::.. ..:.|..
Mouse  1285 KLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMV 1349

  Fly   662 IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQIS------PEQSKRTTM 720
            .....|::||.:.:||.|.|:|||||.:|::|...|.:||.|||...:::      .......:|
Mouse  1350 FCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSM 1414

  Fly   721 VGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNG--KPEIKEK 783
            .||||||||||:....||.|.|:||:|....||..|:||..:.:.:.|::.|..:.  .|.:..
Mouse  1415 RGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPA- 1478

  Fly   784 DKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLK 818
             :.|....||:..||..:...|.|||.||||.|||
Mouse  1479 -RFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	4/17 (24%)
		STKc_PAK_I	558..818	CDD:270814	96/278 (35%)
		S_TKc	566..817	CDD:214567	94/265 (35%)
Map3k19	NP_035867.2	ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1246..1511	CDD:270801	94/267 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910