DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and gck-3

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_507517.2	Gene:	gck-3 / 190400	WormBaseID:	WBGene00013355	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	504	Identity:	157/504 - (31%)
Similarity:	225/504 - (44%)	Gaps:	125/504 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 ATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPS 440
            ::|.|...||    ||.|:..|.||...|     .|:|:|..:..:|:.||....:..:.||..|
Worm     2 SSSNLAGNTN----TTTTSSAASAAAAHS-----AANASTITSEYSTTQTTTGTFNTDTLSSIGS 57

  Fly   441 FHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQV 505
                               ||:...|..|.|     ||      |.|..:.||           :
Worm    58 -------------------TSTLHGSQPSQP-----PP------PPPPQVSSP-----------I 81

  Fly   506 SAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKME 570
            :|...:|           ||:.....|..|...                      :|: .|...|
Worm    82 AAAAAAS-----------AALVAQLNPADRWPT----------------------EPS-AYKLDE 112

  Fly   571 KIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIINEILVMRENKHPNVVNYLDSYLVSE 634
            .||.||:.||:||.......:||||.:||.: |...:.:.:||..|.:..|||||:|..|::..|
Worm   113 SIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQE 177

  Fly   635 ELWVVMEYLPGGSLTDVVTET------------CMDEGQIAAVCREVLQALEFLHANQVIHRDIK 687
            ||||||..|..||:.|::...            .:||..||.|.||||:.||:.|.|..||||||
Worm   178 ELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIK 242

  Fly   688 SDNILLGLDGSVKLTDFGFCAQIS------PEQSKRTTMVGTPYWMAPEVVTRKQ-YGPKVDLWS 745
            :.||||..||::::.|||....::      ..|..|.|.||||.||||||:.:.| |..|.|:||
Worm   243 AGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWS 307

  Fly   746 LGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEI----KEKDKLSS---AFQDFLDQCLEVEVD 803
            |||:|||:..|..||....|:|.|.|...|..|.:    :.||:..:   :|:..:..||:.:..
Worm   308 LGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPA 372

  Fly   804 RRASALDLLKHPFLK-----------LARPLASLTPLIM--AAKEATKG 839
            :|.:|.:|||:.|.|           |...|||: |::.  ::|:...|
Worm   373 KRPTASELLKYSFFKKGKDKKYLVHTLIENLASV-PVVAHHSSKKVASG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	112/286 (39%)
		S_TKc	566..817	CDD:214567	110/277 (40%)
gck-3	NP_507517.2	STKc_OSR1_SPAK	106..386	CDD:270787	110/280 (39%)
gck-3	NP_507517.2	S_TKc	108..386	CDD:214567	110/277 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910