Protein Alignment Pak and Pak3

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001181975.1
• Gene: Pak3 / 18481
• MGIID: 1339656
• Length: 580
• Species: Mus musculus
• Alignment Length: 883
• Identity: 368/883 - (41%)
• Similarity: 431/883 - (48%)
• Gaps: 359/883 - (40%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRK-------- 61
            |:||||||:|:.||   |..|..                :....:|||..|::.::|
Mouse     8 EEKPPAPPLRMNSN---NRDSSA----------------LNHSSKPLPMAPEEKNKKARLRSIFP 53

  Fly    62 ---KKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFT------------------ 105
               .||.|.|.|        .:|.||.|::||||:||||||||||||
Mouse    54 GGGDKTNKKKEK--------ERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSE 110

  Fly   106 ------------------GMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
                              |:||.|||||..|||:|.||||||||||||||::|:..... :.|||
Mouse   111 GKMPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVN-NQKYM 174

  Fly   153 TNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNH 217
                                |.|..|...||               .:..:.:|...|
Mouse   175 --------------------SFTSGDKSAHG---------------YIAAHQSNTKTA------- 197

  Fly   218 YQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQP 282
                      .:.||                     ...||....:.....|||         ..
Mouse   198 ----------SEPPL---------------------APPVSEEEDEEEEEEEDD---------NE 222

  Fly   283 PPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNAT 347
            |||.:|.|||.|||||||.:.:                           .|::|||
Mouse   223 PPPVIAPRPEHTKSIYTRSVVE---------------------------SIASPAA--------- 251

  Fly   348 TTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAH 412
                .||.:..|                      ||.|
Mouse   252 ----PNKEDIPP----------------------SAEN--------------------------- 263

  Fly   413 ATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLP 477
                    |.|||
Mouse   264 --------ANSTT---------------------------------------------------- 268

  Fly   478 PIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKK 542
                             ||.                                   || ....||.
Mouse   269 -----------------LYR-----------------------------------NT-DRQRKKS 280

  Fly   543 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL 607
            ||:|||||||||:|||||||.:|||:.||||||||||||||::.:||.|||||||||.|||||||
Mouse   281 KMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL 345

  Fly   608 IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQA 672
            ||||||||||||:||:|||||||||.:|||||||||.||||||||||||||||||||||||.|||
Mouse   346 IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 410

  Fly   673 LEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQY 737
            |:|||:||||||||||||||||:|||||||||||||||:||||||:|||||||||||||||||.|
Mouse   411 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 475

  Fly   738 GPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEV 802
            |||||:|||||||||||||||||||||||:|||||||||.||::..::||:.|:|||::|||::|
Mouse   476 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 540

  Fly   803 DRRASALDLLKHPFLKLARPLASLTPLIMAAKEATKGN 840
            |||.||.:||:|||||||:||:||||||:|||||.|.:
Mouse   541 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	45/91 (49%)
		STKc_PAK_I	558..818	CDD:270814	217/259 (84%)
Pak3	NP_001181975.1	PBD	69..162	CDD:395634	45/92 (49%)
		STKc_PAK3	284..580	CDD:132987	246/295 (83%)