Protein Alignment Pak and Pak1

DIOPT Version :9

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001344291.1
• Gene: Pak1 / 18479
• MGIID: 1339975
• Length: 552
• Species: Mus musculus
• Alignment Length: 847
• Identity: 374/847 - (44%)
• Similarity: 434/847 - (51%)
• Gaps: 315/847 - (37%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTLKSKI 69
            :|||||||:|.||..         :|.|....|....|.     :|||..|::..:|.:..:|.:
Mouse     9 QDKPPAPPMRNTSTM---------IGAGSKDTGTLNHGS-----KPLPPNPEEKKKKDRFYRSIL 59

  Fly    70 KGSKPSHTDSK--PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAV 132
            .|.|.:....|  |.||.|::||||:||||||||||||||||.|||||..|||:|.|||||||||
Mouse    60 PGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAV 124

  Fly   133 LDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGS 197
            ||||::: |:.|...|.|||:.                      ||......||...|
Mouse   125 LDVLEFY-NSKKTSNSQKYMSF----------------------TDKSAEDYNSSNTL------- 159

  Fly   198 MTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTS 262
                    ||                                               .|||.:.:
Mouse   160 --------NV-----------------------------------------------KTVSETPA 169

  Fly   263 -QHSSANEDDMLGPQHPQQQPPPPPVASRPERTKS--------IYTRPIEDLQPAIIPMPVAPAT 318
             ...|.:|||      .....|||.:|.|||.|||        :|||.:      |.|:||
Mouse   170 VPPVSEDEDD------DDDATPPPVIAPRPEHTKSFGQKDQREVYTRSV------IEPLPV---- 218

  Fly   319 TPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSA 383
                                                                             
Mouse   219 ----------------------------------------------------------------- 218

  Fly   384 TNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTH 448
                   |||.|                        ||||
Mouse   219 -------TPTRD------------------------VATS------------------------- 227

  Fly   449 HALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQ 513
                                             |.|||..:...||
Mouse   228 ---------------------------------PISPTENNTTPPD------------------- 240

  Fly   514 VAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASG 578
                           |.|.||. ...||.||||||||||||:|||||||.:|||:.|||||||||
Mouse   241 ---------------ALTRNTE-KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 289

  Fly   579 TVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYL 643
            |||||::.:||.|||||||||.|||||||||||||||||||:||:|||||||||.:|||||||||
Mouse   290 TVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 354

  Fly   644 PGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCA 708
            .||||||||||||||||||||||||.||||||||:||||||||||||||||:|||||||||||||
Mouse   355 AGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 419

  Fly   709 QISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIA 773
            ||:||||||:|||||||||||||||||.||||||:||||||||||:||||||||||||:||||||
Mouse   420 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA 484

  Fly   774 TNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838
            |||.||::..:|||:.|:|||::|||::|::|.||.:||:|.|||:|:||:||||||.|||||||
Mouse   485 TNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 549

  Fly   839 GN 840
            .|
Mouse   550 NN 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	44/53 (83%)
		STKc_PAK_I	558..818	CDD:270814	215/259 (83%)
		S_TKc	566..817	CDD:214567	208/250 (83%)
Pak1	NP_001344291.1	PBD	74..128	CDD:334253	43/53 (81%)
		STKc_PAK1	256..551	CDD:270820	245/294 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839965
Domainoid	1	1.000	442	1.000	Domainoid score	I536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1936
Inparanoid	1	1.050	629	1.000	Inparanoid score	I850
Isobase	1	0.950	-	0	Normalized mean entropy	S857
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm44337
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890