DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and pak-1

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001024377.1	Gene:	pak-1 / 180873	WormBaseID:	WBGene00003911	Length:	572	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	352/842 - (41%)
Similarity:	418/842 - (49%)	Gaps:	288/842 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSEEDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTLK 66
            ||.::||||||:|.:|:.   .|....||                 ::|||||| ::.:||||:.
Worm     5 SSYDEKPPAPPIRFSSSA---TRENQVVG-----------------LKPLPKEP-EATKKKKTMP 48

  Fly    67 SKI--KGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNP 129
            :..  |.........||.||.|:|||||:|||:|..|||||||||||||||.:|.||||||::||
Worm    49 NPFMKKNKDKKEASEKPVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNP 113

  Fly   130 QAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQ 194
            |||||.||::                                         ..|.:||
Worm   114 QAVLDALKYY-----------------------------------------TQGESSG------- 130

  Fly   195 LGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSS 259
                                        |..||.....:
Worm   131 ----------------------------QKWLQYDMMFI-------------------------- 141

  Fly   260 STSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPL 324
                      ||                  .|.||.|...:|             .|.:|.:.|
Worm   142 ----------DD------------------APSRTPSYGLKP-------------QPYSTSSLP- 164

  Fly   325 QNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCS 389
                             .|.|...  |..|.|     |.||.|::            :..|....
Worm   165 -----------------YHGNKIQ--DPRKMN-----PMTTSTSS------------AGYNSKQG 193

  Fly   390 TTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTI 454
            ..|||                           .|...|..|...|::..|..|.:
Worm   194 VPPTT---------------------------FSVNENRSSMPPSYAPPPVPHGE---------- 221

  Fly   455 HCPTPTSSSRNSTVSFPVAVPLPPIVTPASP-TPASIESPDLYT----PEPTVAQVSAGGPSSQV 514
               ||..                 ||.||.| .||...|  :||    .|..:..:|.|....|.
Worm   222 ---TPAD-----------------IVPPAIPDRPARTLS--IYTKPKEEEEKIPDLSKGQFGVQA 264

  Fly   515 AGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGT 579
            .|.:                     .||||:|.|:|.|||||||:|:|:|||.|::|||.||||:
Worm   265 RGQK---------------------AKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGS 308

  Fly   580 VYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLP 644
            ||||||.||..|||||||||..|||||||||||||||||||.|:|||||||||.:|||||||||.
Worm   309 VYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLA 373

  Fly   645 GGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQ 709
            ||||||||||..|::|.||||||||||||||||:..||||||||||||||:||||||||||||||
Worm   374 GGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQ 438

  Fly   710 ISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIAT 774
            :||||.|||||||||||||||||||||||||||:|||||||||||||||||||||||:|:|||||
Worm   439 LSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIAT 503

  Fly   775 NGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEA 836
            ||||:...:|.::..|:||:|..|||:|:.|.||..||.||||:.|:|||||..||:|||::
Worm   504 NGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKPLASLYYLIVAAKKS 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	41/53 (77%)
		STKc_PAK_I	558..818	CDD:270814	206/259 (80%)
		S_TKc	566..817	CDD:214567	200/250 (80%)
pak-1	NP_001024377.1	PBD	66..121	CDD:279166	41/54 (76%)
		PKc_like	287..547	CDD:304357	206/259 (80%)
		S_TKc	295..546	CDD:214567	200/250 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	411	1.000	Domainoid score	I348
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1936
Inparanoid	1	1.050	629	1.000	Inparanoid score	I466
Isobase	1	0.950	-	0	Normalized mean entropy	S857
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		oto18339
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.960