Protein Alignment Pak and BUB1B-PAK6

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001122100.1
• Gene: BUB1B-PAK6 / 106821730
• HGNCID: 52276
• Length: 681
• Species: Homo sapiens
• Alignment Length: 820
• Identity: 258/820 - (31%)
• Similarity: 358/820 - (43%)
• Gaps: 186/820 - (22%)

  Fly    60 RKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQE 124
            ||||              ..:|.||.|.||:|.||..||...|:|.|:|..|
Human     3 RKKK--------------KKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQW------------- 40

  Fly   125 QKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGN 189
                 |.:||.|:        ||......:.||......:..|...  |:.|.|..:.|..:...
Human    41 -----QNILDTLR--------RPKPVVDPSRITRVQLQPMKTVVRG--SAMPVDGYISGLLNDIQ 90

  Fly   190 LIGVQLGSMTL---GPNANNVAVAGQILGN-HYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSY 250
            .:.| :.|.||   .|.:...|.:..:||: |:.......||..|
Human    91 KLSV-ISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQ-------------------- 134

  Fly   251 NFVGHTVSSSTSQHS---SANEDDMLG-PQHPQQQPPPPPVASRPERTKSIYTRPIE-------D 304
                   |..|..|.   |.|.....| .|.|..:|..|.|.......|:....|.|       .
Human   135 -------SERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRC 192

  Fly   305 LQPAIIPMPVAPATTPATPLQNH-----------------------RTPGGISAPAASPMMHNNA 346
            ||.........|..:|.|....|                       ..|||..:|
Human   193 LQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSP---------- 247

  Fly   347 TTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATA 411
                          ||.|.:::.:.....:.....:||.|..|:.|  .|.|.:...|
Human   248 --------------SPKTRESSLKRRLFRSMFLSTAATAPPSSSKP--GPPPQSKPNS------- 289

  Fly   412 HATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPL 476
                   :.......|..|..:...|.|| ....||...|.|    :.|||.:.|..:.|....|
Human   290 -------SFRPPQKDNPPSLVAKAQSLPS-DQPVGTFSPLTT----SDTSSPQKSLRTAPATGQL 342

  Fly   477 PPIVTPA-SPTP--ASIESPDLYTP-EPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAA 537
            |...:|| ||..  |.|.:.:||.| :||||:.:..|..:.|
Human   343 PGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGV----------------------- 384

  Fly   538 NAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQ 602
                  ::.|:....||.:|..|||........|||:|::|.|..|.|..:|.:||:|.|:|.:|
Human   385 ------VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQ 443

  Fly   603 PKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCR 667
            .::||:.||:::||:.:|.|||....||||.|||||:||:|.||:|||:|::..::|.|||.||.
Human   444 QRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCE 508

  Fly   668 EVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVV 732
            .|||||.:|||..|||||||||:|||.|||.|||:|||||||||.:..||.::|||||||||||:
Human   509 AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI 573

  Fly   733 TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQC 797
            :|..|..:||:||||||.||||:|||||.:::|::|:..:..:..|::|...|:|...:|||::.
Human   574 SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERM 638

  Fly   798 LEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEAT 837
            |..:...||:|.:||.||||........|.|||...::.|
Human   639 LVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQT 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	19/55 (35%)
		STKc_PAK_I	558..818	CDD:270814	137/259 (53%)
BUB1B-PAK6	NP_001122100.1	PBD	11..67	CDD:395634	23/81 (28%)
		STKc_PAK6	385..681	CDD:270821	147/294 (50%)