Protein Alignment Pak and PAK4

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 250/760 - (32%)
• Similarity: 350/760 - (46%)
• Gaps: 197/760 - (25%)

  Fly    83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRP 147
            ||.|:||||.||.|||....:|||:|..|..|:       :|..:.|:.::|            |
Human    11 ISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI-------EESARRPKPLVD------------P 56

  Fly   148 SSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQ 212
            :.                 ::|..|.:..|  .:.||.      |.:.|::||
Human    57 AC-----------------ITSIQPGAPKT--IVRGSK------GAKDGALTL------------ 84

  Fly   213 ILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQH 277
                               ||.:..|   |.:::|:|.
Human    85 -------------------LLDEFEN---MSVTRSNSL--------------------------- 100

  Fly   278 PQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATT----PATPLQNHRTPGGISAPAA 338
             ::..||||..:|.|.                 .||..||||    |.......|..|...|...
Human   101 -RRDSPPPPARARQEN-----------------GMPEEPATTARGGPGKAGSRGRFAGHSEAGGG 147

  Fly   339 SPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRG 403
            |            .::..|.|..  ..|::.|..|....|        |....|.:.|....|:.
Human   148 S------------GDRRRAGPEK--RPKSSREGSGGPQES--------SRDKRPLSGPDVGTPQP 190

  Fly   404 SLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTV 468
            :        ...:.|.:|         :...|:::|....|..:..|....|...|...|...
Human   191 A--------GLASGAKLA---------AGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGG-- 236

  Fly   469 SFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAA------VA 527
               :|:|               :|....:..||.|:   |.||..|.|...:.||.|      .|
Human   237 ---LAIP---------------QSSSSSSRPPTRAR---GAPSPGVLGPHASEPQLAPPACTPAA 280

  Fly   528 PA--ATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGM 590
            ||  ..|..|:...:.:::|.|:....|:.:|..|||........|||:|::|.|..|...|:|.
Human   281 PAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGK 345

  Fly   591 EVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTET 655
            .||:|:|:|.:|.::||:.||:::||:.:|.|||...:||||.:|||||||:|.||:|||:||.|
Human   346 LVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT 410

  Fly   656 CMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTM 720
            .|:|.||||||..|||||..|||..|||||||||:|||..||.|||:|||||||:|.|..:|.::
Human   411 RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL 475

  Fly   721 VGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDK 785
            ||||||||||:::|..|||:||:||||||.||||:|||||.||.||||:.:|..|..|.:|...|
Human   476 VGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 540

  Fly   786 LSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            :|.:.:.|||:.|..:..:||:|.:|||||||..|.|.||:.||:
Human   541 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	21/55 (38%)
		STKc_PAK_I	558..818	CDD:270814	147/259 (57%)
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	20/50 (40%)
		Linker	25..320		89/479 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		57/312 (18%)
		GEF-interaction domain (GID)	298..323		7/24 (29%)
		STKc_PAK4	300..591	CDD:132988	158/286 (55%)