Protein Alignment Pak and pak6

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_003200338.1
• Gene: pak6 / 100536197
• -ID: -
• Length: 693
• Species: Danio rerio
• Alignment Length: 813
• Identity: 259/813 - (31%)
• Similarity: 360/813 - (44%)
• Gaps: 174/813 - (21%)

  Fly    60 RKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQE 124
            ||||              ..:|.||.|.||||.||..|||..|.|.|:|..|..|:  .|:.:.:
Zfish     3 RKKK--------------KKRPEISAPKNFEHRVHTSFDAKRGVFVGLPTQWQSLI--ENLRRPK 51

  Fly   125 QKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSG------SSLSRVSSSSPSSTPTDSELHG 183
            ...:|..:..|        :.:|....:..::..|..      |.:||:|.:|.:|....|.  .
Zfish    52 PMVDPSRITPV--------ELKPKKTIVRGSMIGHGDYISAMLSDMSRLSVTSSNSLRKSSP--S 106

  Fly   184 SNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQP-------LLHQNHNQHH 241
            :......:| :||.:       |.|.|   ||:.||.:   .|...:|       .:|......:
Zfish   107 ARKRAQSLG-RLGEL-------NEADA---LGDGYQYE---TLDDPEPHWSERARNIHSASGTPY 157

  Fly   242 MGISQSHSYNFVGHTV-SSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDL 305
            ||:.:|.:....|... :.||.:.|.:..|..| |.||...|||||
Zfish   158 MGLKKSVTLQPNGILPRAKSTYEVSMSCLDGPL-PPHPALPPPPPP------------------- 202

  Fly   306 QPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAE 370
                 |.||   ..|..||.   ..|.|.:|....||..........|....|.....|.....:
Zfish   203 -----PFPV---PEPPRPLY---LAGDIGSPTERLMMRREFPIIFTHNPRPITCFYSPTQMPMQQ 256

  Fly   371 TEGTDATSTLLSAT-----------NPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATST 424
            ..|...|..:.||.           .|..|....:|.....|.|.|      |:.|::..|:..
Zfish   257 PHGDSLTPDMRSANRLLVHPQNSPGRPFSSYDLKSDSGMRPPAGFL------HSGTSSPLVSGG- 314

  Fly   425 TTNHHSSASSFSSF-----------PSFHDDDGTHHAL------PTIHCPTPTSSSRNSTVSFPV 472
              .|.:|..|..|:           |...|....|..|      |:...|:||.|..:|    |.
Zfish   315 --RHQASVRSSCSYTLGLSPNISYRPPAPDPFMRHSGLYPRQDSPSQPRPSPTGSLAHS----PP 373

  Fly   473 AVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAA 537
            ....|....|..|:|..       .|:|
Zfish   374 GTCSPAFRAPQQPSPRP-------PPDP------------------------------------- 394

  Fly   538 NAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQ 602
                .|::.|:....|:.:|..|||........|||:|::|.|..|.|..:|..||:|.|:|.:|
Zfish   395 ----PKVTHEQFKAALQMVVDKGDPRSYLENFVKIGEGSTGVVCIAREKHSGRVVAVKMMDLRRQ 455

  Fly   603 PKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCR 667
            .::||:.||:::||:.:|.|||....|.||.|||||:||||.||:||::|:||.:.|.|||.||.
Zfish   456 QRRELLFNEVVIMRDYQHRNVVEMFKSALVEEELWVIMEYLQGGALTNIVSETRLSEEQIATVCE 520

  Fly   668 EVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVV 732
            .|||||.:||:..|||||||||:|||.|||.:||:|||||||||.:..||.::|||||||||||:
Zfish   521 AVLQALAYLHSQGVIHRDIKSDSILLSLDGRIKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVI 585

  Fly   733 TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQC 797
            ::..||.:||:||||||.:|||:|||||.:|.|:.|:..:.....|.::...::|...:||||:.
Zfish   586 SKSPYGTEVDVWSLGIMVVEMVDGEPPYFSETPVAAMKRLRDELAPTVRNVHQVSPMLKDFLDRM 650

  Fly   798 LEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830
            |..:...||||.|||:||||..|.....|.||:
Zfish   651 LTRDPLERASATDLLEHPFLLQASSPQCLVPLV 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	21/55 (38%)
		STKc_PAK_I	558..818	CDD:270814	137/259 (53%)
pak6	XP_003200338.1	CRIB_PAK_like	10..55	CDD:238526	20/46 (43%)
		Protein Kinases, catalytic domain	397..693	CDD:473864	145/287 (51%)