Protein Alignment Pak and pak1

DIOPT Version :10

• Sequence 1: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_017947249.1
• Gene: pak1 / 100135731
• XenbaseID: XB-GENE-967716
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 337/846 - (39%)
• Similarity: 406/846 - (47%)
• Gaps: 346/846 - (40%)

  Fly     5 EDKPPAPPVRLTSNRGGNERSGGGVGVGGGGLGGGGMGDVPPDMRPLPKEPDDSDRKKKTLKSKI 69
            |||.|.||:|:.|.            :|||                   ..:..:.|.|.:|...
 Frog     9 EDKAPPPPIRINST------------IGGG-------------------NTNKWNEKDKKIKKGE 42

  Fly    70 KGSKPSHTDSKPN---------ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQ 125
            :.|:|.:...|.|         ||.|..:||..|||.|..||||||||:.||:||..:||||.:|
 Frog    43 EKSQPFNFPHKGNKKVKNPPLVISSPFGYEHIYHVGIDPSTGEFTGMPKQWAQLLQTANISKIDQ 107

  Fly   126 KKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNL 190
            |||||.|||||.::.:.|..: |.|||                    |.|....|.:.|||
 Frog   108 KKNPQVVLDVLNFYSSETTSK-SQKYM--------------------SFTDNSREAYNSNS---- 147

  Fly   191 IGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGH 255
                    .|  :|..|....::|                |:
 Frog   148 --------VL--DAKPVPEVAEVL----------------PV----------------------- 163

  Fly   256 TVSSSTSQHSSANEDDMLGPQHPQQQPPP--PPVASRPERTKSIYTRPIEDLQPAIIPMPVAPAT 318
                                  |:.:.||  ||   ||:.|||||||.:  ::|.:.|:...|.|
 Frog   164 ----------------------PEAEDPPAFPP---RPDHTKSIYTRSV--IEPPVPPLAAKPTT 201

  Fly   319 TPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSA 383
            ...:.:    |.|              |.:::||.|
 Frog   202 ENGSSV----TDG--------------AESSVDKTK----------------------------- 219

  Fly   384 TNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTH 448
                                                                             
 Frog   220 ----------------------------------------------------------------- 219

  Fly   449 HALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQ 513
                                                                             
 Frog   220 ----------------------------------------------------------------- 219

  Fly   514 VAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASG 578
                                      ||.||:|||||||||:|||||||.:|||:.|||||||||
 Frog   220 --------------------------KKPKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 258

  Fly   579 TVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYL 643
            |||.|::.:||.|||||||||.||||||||||||||||||||||:|||||||||.||||||||||
 Frog   259 TVYIAVDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHPNIVNYLDSYLVGEELWVVMEYL 323

  Fly   644 PGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCA 708
            .|||||||||||||.||:|||||||.||||||||:||||||||||||||||:||:||||||||||
 Frog   324 AGGSLTDVVTETCMQEGEIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGAVKLTDFGFCA 388

  Fly   709 QISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIA 773
            ||||||:||:|||||||||||||||||.||||||:|||||||||||||||||||||||:||||||
 Frog   389 QISPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIA 453

  Fly   774 TNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838
            |||.|:::|.:|.|.||:|||.:|||::|::|.||.|||:|||||:|:|::||||.|:..|:..|
 Frog   454 TNGTPQLQEPEKKSPAFRDFLSRCLEMDVEKRGSARDLLQHPFLKVAKPMSSLTPYIITGKQMAK 518

  Fly   839 G 839
            |
 Frog   519 G 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..139	CDD:395634	36/55 (65%)
		STKc_PAK_I	558..818	CDD:270814	216/259 (83%)
pak1	XP_017947249.1	CRIB_PAK_like	63..108	CDD:238526	25/44 (57%)
		STKc_PAK_I	238..498	CDD:270814	216/259 (83%)