DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak and pak4

DIOPT Version :9

Sequence 1:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_012823244.1	Gene:	pak4 / 100036644	XenbaseID:	XB-GENE-1013749	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	253/807 - (31%)
Similarity:	358/807 - (44%)	Gaps:	202/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQE 124
            :|||.::                ||.|.||||.||.|||....:|||:|..|..|:       :|
Frog    19 KKKKRIE----------------ISAPLNFEHRVHTGFDQQEQKFTGLPRQWQSLI-------EE 60

  Fly   125 QKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGS-----------SLSRVSS---SSPSST 175
            ..|.|:.::|  ..:..|....|....:..:..:..||           |:.|.:|   .||...
Frog    61 SAKRPKPLVD--PSYITTINHVPQKTIVRGSKMSLDGSLAWLLDEFDAMSICRSNSLRRESPPCH 123

  Fly   176 PTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQH 240
            |.:...|..|                 ..:.|.|          :||:   :..|....:|.::|
Frog   124 PREDRFHQEN-----------------GMSEVRV----------RQQR---EDGQRGSERNRSEH 158

  Fly   241 HMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPP-----PPPVASRPERTKSIYTR 300
                                 |:.....|:....||.|:.|.|     |||    |:..|.|..:
Frog   159 ---------------------SRRERQREEHKAVPQQPRGQEPSNKHRPPP----PDYPKDIPEK 198

  Fly   301 ---------------PIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTL 350
                           |:.|                          .|.|.|....:.........
Frog   199 RGTRSHEKGDGRREYPVND--------------------------RGYSEPVERVVKREKGEEKR 237

  Fly   351 DKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATT 415
            .|:...:...||.:.:......|            ||..|     |..::..|.:.:|.|..|
Frog   238 PKSSYTSAEGSPQSPRDKRPLSG------------PSIRT-----PGSSSTEGVVKQTQTGRA-- 283

  Fly   416 AAATVATSTTTNHHSSASSFSSFPSFHDDD--GTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPP 478
                               |:::|....|.  |..|.:|..|...|..|  .||||...:.|...
Frog   284 -------------------FNTYPRAETDPSRGAPHQVPDSHSTVPLDS--KSTVSKSSSRPQQG 327

  Fly   479 IVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKK 543
            .|.|..|.          .|.||.....:..|       |::.|.....||   ..|:...:.::
Frog   328 QVKPKLPD----------KPHPTQLVPHSSDP-------QLSHPVQTQHPA---QPRSPQREPQR 372

  Fly   544 MSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELI 608
            :|.|:....|:.:|..|||........|||:|::|.|..|...|:|..||:|:|:|.:|.::||:
Frog   373 VSHEQFRAALQMVVDPGDPRTYLDNFIKIGEGSTGIVCIATIKSSGKLVAVKKMDLRKQQRRELL 437

  Fly   609 INEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQAL 673
            .||:::||:.:|.|||...:||||.:||||:||:|.||:|||:||.|.|:|.|||.||..||:||
Frog   438 FNEVVIMRDYQHENVVEMYNSYLVGDELWVIMEFLEGGALTDIVTHTRMNEEQIATVCVSVLKAL 502

  Fly   674 EFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYG 738
            ..|||..|||||||||:|||..||.|||:|||||||::.|..:|.::||||||||||:::|..||
Frog   503 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVNKEVPRRKSLVGTPYWMAPELISRLPYG 567

  Fly   739 PKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVD 803
            |:||:||||||.||||:|||||.||.||||:.:|..|..|::|...|:|...:.|||:.|..:..
Frog   568 PEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNAQKVSPLLKGFLDRLLVRDPS 632

  Fly   804 RRASALDLLKHPFLKLARPLASLTPLI 830
            :||||.:|||||||..|.|.:.:.||:
Frog   633 QRASANELLKHPFLGKAGPPSCIVPLM 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak	NP_001138013.2	PBD	83..137	CDD:279166	22/53 (42%)
		STKc_PAK_I	558..818	CDD:270814	144/259 (56%)
		S_TKc	566..817	CDD:214567	140/250 (56%)
pak4	XP_012823244.1	CRIB_PAK_like	24..70	CDD:238526	21/68 (31%)
pak4	XP_012823244.1	PKc_like	374..665	CDD:389743	153/286 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920