Protein Alignment msn and MAP4K4

DIOPT Version :9

• Sequence 1: NP_524679.3
• Gene: msn / 44030
• FlyBaseID: FBgn0010909
• Length: 1504
• Species: Drosophila melanogaster
• Sequence 2: NP_001381931.1
• Gene: MAP4K4 / 9448
• HGNCID: 6866
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1624
• Identity: 714/1624 - (43%)
• Similarity: 894/1624 - (55%)
• Gaps: 383/1624 - (23%)

  Fly    16 SLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVL 80
            ||.||||::|:||||||||:||||||||||||||||.||||||||||||||||||||||||||:|
Human     9 SLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINML 73

  Fly    81 KKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREIL 145
            ||||:||||||||||||||||||.|||||||||:|||||:|||||:|||.:|||:|||||.||||
Human    74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 138

  Fly   146 RGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACD 210
            |||::||.:.||||||||||||||:||||||||||||||||||:|||||||||||||||||||||
Human   139 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 203

  Fly   211 ENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDT 275
            ||||||||.||||||.||||:||||..|||||:||||||||||||.|||||||||||||..||:.
Human   204 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEG 268

  Fly   276 VLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDNDDDE- 339
            .|||:|.|||.||.||||.||:|||.:|||||||||||||.:|::.||:..:|.||||:.:::|
Human   269 CLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV 333

  Fly   340 PQLAGEHSSIVQAPGGDTLRRNF-----------------QQIQEGRLAAEQQQQHHLMAQAQ-- 385
            |:..||.||||..||..||||:|                 |.:||.:|..:::.:..|:|:.|
Human   334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398

  Fly   386 -------------AQAAAAHAAAQAQAQ------------------------------------- 400
                         .|.....|..|.:.:
Human   399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER 463

  Fly   401 ------------------LQQQ--QQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQA--------N 437
                              ||||  |:||...........:..|....|.|.||.||        :
Human   464 EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH 528

  Fly   438 RQPKPPSRQQVEEPGPPARPPQRLIVVPDPPHANRPLP----PTPKCG-EPAGQTPQQQQRNSQN 497
            |:|.|...||                 |.||...|..|    |.||.. |||.:..:.:.|..:.
Human   529 RRPHPQHSQQ-----------------PPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKT 576

  Fly   498 NFKPSLPPRRPEPQPQTAAGGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQ 562
            |..      .||.|         |:|..:...||..:|..|  .|:|.|.|......:||.  ||
Human   577 NHS------SPEAQ---------SKQTGRVLEPPVPSRSES--FSNGNSESVHPALQRPAE--PQ 622

  Fly   563 QSNNHLGQPVNPLDPLDSSDSDSEPDEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSH 627
            ...:||....|.:.|:..|.|.|:| .|.....:   |.:.||
Human   623 VQWSHLASLKNNVSPVSRSHSFSDP-SPKFAHHH---LRSQDP---------------------- 661

  Fly   628 GSGGPPNRP--LPPTPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPS----RRGDESN 686
               .||:|.  |..:.|...:|.|.|              ||:.|.|.::..|.    |....|.
Human   662 ---CPPSRSEVLSQSSDSKSEAPDPT--------------QKAWSRSDSDEVPPRVPVRTTSRSP 709

  Fly   687 LLRDWDFDRFFPKNANGPRGSGRGSPTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQ 751
            :|...|    .|...:|.:.|..|...:|:|           ::.:|    :.|.:.:.|||
Human   710 VLSRRD----SPLQGSGQQNSQAGQRNSTSS-----------IEPRL----LWERVEKLVPR--- 752

  Fly   752 PLKAEPSASQSIAKEQGSASGSGSGSGS----ASGSGSGGSTNSPAHKRQDSDSRLPTNFERGFR 812
            |.....|.|.:...:.||..||.||||.    .|.|.|.||.:    :|.::..:.|.:.:..||
Human   753 PGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPS----QRLENAVKKPEDKKEVFR 813

  Fly   813 ----RENSDFFPLAKRYSAVFSGASASGSTAGSPSAQALQRSSAVYQRNSIYSSSISSKSKENDV 873
                ....|...|||...||                :.::....|...:|....|.::..:::||
Human   814 PLKPAGEVDLTALAKELRAV----------------EDVRPPHKVTDYSSSSEESGTTDEEDDDV 862

  Fly   874 PGAPGAAAAGTATASAKPGPAAATTTATKGAAPKTSKSLANFHF-----LRPRREKTESVIVLQN 933
            .    ...|..:|:..:...||::...:.|........:.:...     :.|.:|.|  :||
Human   863 E----QEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGT--LIV--- 918

  Fly   934 AAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGGSSGVGADGTGLGTPGTRTSSVL 998
                           :|..:.|::...:...|..|                         ...:|
Human   919 ---------------RQSTVDQKRASHHESNGFAG-------------------------RIHLL 943

  Fly   999 PDLLSQASPATPPRHDKSSSEEYQAAISSSVHSTPSKSFIASSGSGGLGLGGGTVVGGVIISSNH 1063
            ||||.|:       |..|         :||..|:||.|
Human   944 PDLLQQS-------HSSS---------TSSTSSSPSSS--------------------------- 965

  Fly  1064 SPQSTISLASSSSNSRQNSPKNSI--SKTRSSSSITNLLHKSASSSS----ANLHHLTPCSSTSS 1122
            .|..|:|         ..:|::.:  ::|:|:|| |...|||:||.:    ..|..::|.|.|:.
Human   966 QPTPTMS---------PQTPQDKLTANETQSASS-TLQKHKSSSSFTPFIDPRLLQISPSSGTTV 1020

  Fly  1123 ASISNPLPPHAYALQQKQRSFLTFGFGAGG-------SGPSRRESHVNVNVTPTSHEAANDTPEI 1180
            .|:                    .||...|       ..|:|:.|.||||  ||:....:|||||
Human  1021 TSV--------------------VGFSCDGMRPEAIRQDPTRKGSVVNVN--PTNTRPQSDTPEI 1063

  Fly  1181 RKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTIS 1245
            ||||||||||||||||||||||:|||:||||||||||||||.||:|||||||:||||.|:|||||
Human  1064 RKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS 1128

  Fly  1246 GKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAVHFKIVKYERIKFLVIALKDSI 1310
            |||:::||||||||::|||..|   .:||::.||..||||:|.||:|:||||||||||||||.|:
Human  1129 GKKDKLRVYYLSWLRNKILHND---PEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSV 1190

  Fly  1311 EIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLP 1375
            |:|||||||||||||||:||||.|:|||||||:|:..||||||||..||||||:||..|||||||
Human  1191 EVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLP 1255

  Fly  1376 KHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMG 1440
            .|.|.:|.||.|:.|||::||:||:||::|||||||.||::|::||||||||||||||.:.|.||
Human  1256 THIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMG 1320

  Fly  1441 WGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTLNKPGMANW 1504
            ||.|||||||||:||||||||||:||||||||||||||||:|.:...|.|:|||||.:..:.:|
Human  1321 WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	233/270 (86%)
		S_TKc	32..296	CDD:214567	227/263 (86%)
		CNH	1183..1484	CDD:214481	230/300 (77%)
MAP4K4	NP_001381931.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I423
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1136	1.000	Inparanoid score	I219
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46069
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	1	1.000	-	-		FOG0001422
OrthoInspector	1	1.000	-	-		otm41041
orthoMCL	1	0.900	-	-		OOG6_101812
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840